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Q0S9X0

- ACDH2_RHOJR

UniProt

Q0S9X0 - ACDH2_RHOJR

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Protein

Acetaldehyde dehydrogenase 2

Gene

RHA1_ro03866

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
Binding sitei266 – 2661NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi157 – 1659NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-3863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:RHA1_ro03866
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Acetaldehyde dehydrogenase 2PRO_0000387727Add
BLAST

Proteomic databases

PRIDEiQ0S9X0.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro03866.

Structurei

3D structure databases

ProteinModelPortaliQ0S9X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
OMAiQPELPDF.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S9X0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLKAAIVG SGNIGTDLMY KLLRSEHVEP VCMVGIDPDS EGLARARQEG
60 70 80 90 100
LEASAGGLDW LLAQPELPDF VFEATSAKIH AAAAPRYADA GITAIDLTPA
110 120 130 140 150
SVGPYVVPAV NLDAHLSAPN VNMVSCAGQA TIPILYAINE VADASYGEIV
160 170 180 190 200
AAIASHSAGP GTRQNLSEFS EKTGRALAQV AGADRAKAIS VINPAEPPMN
210 220 230 240 250
MRDTVYAKVR NPDPAAIERA VVDMVAKVQR YVPGYSLRLV DVDGDLVTVM
260 270 280 290
LEVVGAGDFL PTYAGNLDII TAAAVQVADV MAQQNLVQGA AQ
Length:292
Mass (Da):30,432
Last modified:September 5, 2006 - v1
Checksum:i4360DD32A03A901E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95666.1.
RefSeqiYP_703824.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG95666; ABG95666; RHA1_ro03866.
GeneIDi4221417.
KEGGirha:RHA1_ro03866.
PATRICi23206591. VBIRhoJos26306_3893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95666.1 .
RefSeqi YP_703824.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0S9X0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro03866.

Proteomic databases

PRIDEi Q0S9X0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG95666 ; ABG95666 ; RHA1_ro03866 .
GeneIDi 4221417.
KEGGi rha:RHA1_ro03866.
PATRICi 23206591. VBIRhoJos26306_3893.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
OMAi QPELPDF.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-3863-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiACDH2_RHOJR
AccessioniPrimary (citable) accession number: Q0S9X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3