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Q0S8D5

- PANC_RHOSR

UniProt

Q0S8D5 - PANC_RHOSR

Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton donorUniRule annotation
    Binding sitei73 – 731Beta-alanineUniRule annotation
    Binding sitei73 – 731PantoateUniRule annotation
    Binding sitei165 – 1651PantoateUniRule annotation
    Binding sitei188 – 1881ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi42 – 498ATPUniRule annotation
    Nucleotide bindingi159 – 1624ATPUniRule annotation
    Nucleotide bindingi196 – 1994ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-4412-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:RHA1_ro04415
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Pantothenate synthetasePRO_0000305529Add
    BLAST

    Proteomic databases

    PRIDEiQ0S8D5.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro04415.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0S8D5.
    SMRiQ0S8D5. Positions 7-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiPTHFAGM.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0S8D5-1 [UniParc]FASTAAdd to Basket

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    MSDLQGGYKR GELTVHHDPS VLTRVSKALR GVGRQVALVP TMGALHTGHL    50
    ELVRQAKLTG AVVIVSIFVN PLQFGAGEDL DAYPRTLDAD LELLREAGVE 100
    LAFVPTAATM YPAGPRTTIH PGPLGAELEG VSRPTHFAGM LTVVAKLLQI 150
    AAPNVAYFGE KDYQQLTLIR QMVTDLNFDV RIFGVPTVRE HDGLALSSRN 200
    RYLDEAQRSA ATALSAALIA GAHAAAGGAE AILATAREVL ASVPEVEVDY 250
    LEVRGVDLGP APERGDGRLL VAAKVGTTRL IDNVGVAVGT GFLERDAEPP 300
    SDASAADELL SR 312
    Length:312
    Mass (Da):32,922
    Last modified:September 5, 2006 - v1
    Checksum:i9DF1D28D3313099C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96201.1.
    RefSeqiYP_704359.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG96201; ABG96201; RHA1_ro04415.
    GeneIDi4221966.
    KEGGirha:RHA1_ro04415.
    PATRICi23207719. VBIRhoJos26306_4444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96201.1 .
    RefSeqi YP_704359.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0S8D5.
    SMRi Q0S8D5. Positions 7-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro04415.

    Proteomic databases

    PRIDEi Q0S8D5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG96201 ; ABG96201 ; RHA1_ro04415 .
    GeneIDi 4221966.
    KEGGi rha:RHA1_ro04415.
    PATRICi 23207719. VBIRhoJos26306_4444.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi PTHFAGM.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci RJOS101510:GJJ1-4412-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiPANC_RHOSR
    AccessioniPrimary (citable) accession number: Q0S8D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3