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Q0S8D5

- PANC_RHOSR

UniProt

Q0S8D5 - PANC_RHOSR

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Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton donorUniRule annotation
Binding sitei73 – 731Beta-alanineUniRule annotation
Binding sitei73 – 731PantoateUniRule annotation
Binding sitei165 – 1651PantoateUniRule annotation
Binding sitei188 – 1881ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 498ATPUniRule annotation
Nucleotide bindingi159 – 1624ATPUniRule annotation
Nucleotide bindingi196 – 1994ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-4412-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:RHA1_ro04415
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Pantothenate synthetasePRO_0000305529Add
BLAST

Proteomic databases

PRIDEiQ0S8D5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi101510.RHA1_ro04415.

Structurei

3D structure databases

ProteinModelPortaliQ0S8D5.
SMRiQ0S8D5. Positions 7-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S8D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLQGGYKR GELTVHHDPS VLTRVSKALR GVGRQVALVP TMGALHTGHL
60 70 80 90 100
ELVRQAKLTG AVVIVSIFVN PLQFGAGEDL DAYPRTLDAD LELLREAGVE
110 120 130 140 150
LAFVPTAATM YPAGPRTTIH PGPLGAELEG VSRPTHFAGM LTVVAKLLQI
160 170 180 190 200
AAPNVAYFGE KDYQQLTLIR QMVTDLNFDV RIFGVPTVRE HDGLALSSRN
210 220 230 240 250
RYLDEAQRSA ATALSAALIA GAHAAAGGAE AILATAREVL ASVPEVEVDY
260 270 280 290 300
LEVRGVDLGP APERGDGRLL VAAKVGTTRL IDNVGVAVGT GFLERDAEPP
310
SDASAADELL SR
Length:312
Mass (Da):32,922
Last modified:September 5, 2006 - v1
Checksum:i9DF1D28D3313099C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG96201.1.
RefSeqiYP_704359.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG96201; ABG96201; RHA1_ro04415.
GeneIDi4221966.
KEGGirha:RHA1_ro04415.
PATRICi23207719. VBIRhoJos26306_4444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG96201.1 .
RefSeqi YP_704359.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0S8D5.
SMRi Q0S8D5. Positions 7-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro04415.

Proteomic databases

PRIDEi Q0S8D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG96201 ; ABG96201 ; RHA1_ro04415 .
GeneIDi 4221966.
KEGGi rha:RHA1_ro04415.
PATRICi 23207719. VBIRhoJos26306_4444.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci RJOS101510:GJJ1-4412-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiPANC_RHOSR
AccessioniPrimary (citable) accession number: Q0S8D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3