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Q0S816

- ACDH3_RHOSR

UniProt

Q0S816 - ACDH3_RHOSR

Protein

Acetaldehyde dehydrogenase 3

Gene

hsaG

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
    Binding sitei276 – 2761NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi157 – 1659NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16914.
    RJOS101510:GJJ1-4531-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
    Gene namesi
    Name:hsaG
    Ordered Locus Names:RHA1_ro04534
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Acetaldehyde dehydrogenase 3PRO_0000387728Add
    BLAST

    Proteomic databases

    PRIDEiQ0S816.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro04534.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0S816.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiDIQQYVP.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0S816-1 [UniParc]FASTAAdd to Basket

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    MTKASVAIVG SGNISTDLLY KLQRSEWLEP RWMIGIDPES EGLARARKLG    50
    LETSAEGVDW LLNQPEKPDL VFEATSAYVH REAAPRYEAA GIRAVDLTPA 100
    AVGPAVVPPA NLREHLGAPN VNMITCGGQA TIPIVYAVSR VVDVPYAEIV 150
    ASVASVSAGP GTRANIDEFT KTTSRGIETI GGAQRGKAII ILNPADPPMI 200
    MRDTIFCAIP EDADRAAITD SIHRVVADIQ QYVPGYRLLN EPQFDDPSVV 250
    SGGQATVTTF VEVEGAGDFL PPYAGNLDIM TAAATKVGEE IAQKLLSVEA 300
    Length:300
    Mass (Da):31,847
    Last modified:September 5, 2006 - v1
    Checksum:i1DB014434D741892
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96320.1.
    RefSeqiYP_704478.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG96320; ABG96320; RHA1_ro04534.
    GeneIDi4222085.
    KEGGirha:RHA1_ro04534.
    PATRICi23207971. VBIRhoJos26306_4570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96320.1 .
    RefSeqi YP_704478.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0S816.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro04534.

    Proteomic databases

    PRIDEi Q0S816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG96320 ; ABG96320 ; RHA1_ro04534 .
    GeneIDi 4222085.
    KEGGi rha:RHA1_ro04534.
    PATRICi 23207971. VBIRhoJos26306_4570.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi DIQQYVP.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-16914.
    RJOS101510:GJJ1-4531-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiACDH3_RHOSR
    AccessioniPrimary (citable) accession number: Q0S816
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3