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Protein

HTH-type transcriptional repressor KstR2

Gene

kstR2

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Controls the expression of a small regulon that may play a role in the utilization of cholesterol.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi36 – 55H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR2
Gene namesi
Name:kstR2
Ordered Locus Names:RHA1_ro04598
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004050331 – 204HTH-type transcriptional repressor KstR2Add BLAST204

Proteomic databases

PRIDEiQ0S7V2.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro04598.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 30Combined sources19
Helixi37 – 43Combined sources7
Helixi48 – 54Combined sources7
Helixi58 – 82Combined sources25
Helixi87 – 104Combined sources18
Helixi106 – 114Combined sources9
Helixi117 – 119Combined sources3
Helixi123 – 125Combined sources3
Helixi126 – 148Combined sources23
Helixi158 – 168Combined sources11
Helixi171 – 174Combined sources4
Beta strandi180 – 182Combined sources3
Helixi184 – 197Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IBDX-ray1.50A/B1-204[»]
ProteinModelPortaliQ0S7V2.
SMRiQ0S7V2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0S7V2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 73HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108RZE. Bacteria.
ENOG4111HHS. LUCA.
HOGENOMiHOG000249907.
OMAiANERFTY.
OrthoDBiPOG091H02BD.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0S7V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPPADDTS GKSGRRTELL DIAATLFAER GLRATTVRDI ADAAGILSGS
60 70 80 90 100
LYHHFDSKES MVDEILRGFL DDLFGKYREI VASGLDSRAT LEALVTTSYE
110 120 130 140 150
AIDASHSAVA IYQDEVKHLV ANERFTYLSE LNTEFRELWM GVLEAGVKDG
160 170 180 190 200
SFRSDIDVEL AFRFLRDTAW VAVRWYRPGG SVTVDTVAKQ YLSIVLDGLA

SPHN
Length:204
Mass (Da):22,550
Last modified:September 5, 2006 - v1
Checksum:i6C9FD9985640EEFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG96384.1.
RefSeqiWP_009477673.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG96384; ABG96384; RHA1_ro04598.
GeneIDi4222149.
KEGGirha:RHA1_ro04598.
PATRICi23208105. VBIRhoJos26306_4637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG96384.1.
RefSeqiWP_009477673.1. NC_008268.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IBDX-ray1.50A/B1-204[»]
ProteinModelPortaliQ0S7V2.
SMRiQ0S7V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi101510.RHA1_ro04598.

Proteomic databases

PRIDEiQ0S7V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG96384; ABG96384; RHA1_ro04598.
GeneIDi4222149.
KEGGirha:RHA1_ro04598.
PATRICi23208105. VBIRhoJos26306_4637.

Phylogenomic databases

eggNOGiENOG4108RZE. Bacteria.
ENOG4111HHS. LUCA.
HOGENOMiHOG000249907.
OMAiANERFTY.
OrthoDBiPOG091H02BD.

Miscellaneous databases

EvolutionaryTraceiQ0S7V2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKSTR2_RHOJR
AccessioniPrimary (citable) accession number: Q0S7V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.