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Q0S679

- TRMB_RHOSR

UniProt

Q0S679 - TRMB_RHOSR

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, RHA1_ro05176
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901S-adenosyl-L-methionine By similarity
Binding sitei115 – 1151S-adenosyl-L-methionine By similarity
Binding sitei142 – 1421S-adenosyl-L-methionine By similarity
Active sitei165 – 1651 By similarity
Binding sitei165 – 1651S-adenosyl-L-methionine By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei201 – 2011Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-5173-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:RHA1_ro05176
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288211Add
BLAST

Proteomic databases

PRIDEiQ0S679.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro05176.

Structurei

3D structure databases

ProteinModelPortaliQ0S679.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 2384Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiFATDWEN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0S679-1 [UniParc]FASTAAdd to Basket

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MPETPLMRDN GPVNHADQDA PAVPEEGQTK DSKGSRLHPR VTSFRSRRGA    50
LTVAQQESWD RQWPRIGADV SDHRLDAPSW FGRDAPLILE IGSGTGTATA 100
AMAKAEPHVN LMAVEVYRPG LAQLLQQIER DEIPNIRVLR GDAMDVLENM 150
IEPESLTGVR VFFPDPWPKA RHHKRRLLQS PTFALIASRL KAGGVLHVAT 200
DHAEYAEAIA EAGNAEPLLT SLDWESPMTH ERPVTKFEDK AHQVGSAITE 250
LIWGKIRS 258
Length:258
Mass (Da):28,586
Last modified:September 5, 2006 - v1
Checksum:iCD758B30746B1F02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG96957.1.
RefSeqiYP_705115.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG96957; ABG96957; RHA1_ro05176.
GeneIDi4222727.
KEGGirha:RHA1_ro05176.
PATRICi23209297. VBIRhoJos26306_5228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG96957.1 .
RefSeqi YP_705115.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0S679.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro05176.

Proteomic databases

PRIDEi Q0S679.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG96957 ; ABG96957 ; RHA1_ro05176 .
GeneIDi 4222727.
KEGGi rha:RHA1_ro05176.
PATRICi 23209297. VBIRhoJos26306_5228.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi FATDWEN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci RJOS101510:GJJ1-5173-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiTRMB_RHOSR
AccessioniPrimary (citable) accession number: Q0S679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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