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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90S-adenosyl-L-methionineUniRule annotation1
Binding sitei115S-adenosyl-L-methionineUniRule annotation1
Binding sitei142S-adenosyl-L-methionineUniRule annotation1
Active sitei165By similarity1
Binding sitei165S-adenosyl-L-methionineUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei201SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RHA1_ro05176
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882111 – 258tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST258

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro05176

Structurei

3D structure databases

ProteinModelPortaliQ0S679
SMRiQ0S679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 238Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q0S679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPETPLMRDN GPVNHADQDA PAVPEEGQTK DSKGSRLHPR VTSFRSRRGA
60 70 80 90 100
LTVAQQESWD RQWPRIGADV SDHRLDAPSW FGRDAPLILE IGSGTGTATA
110 120 130 140 150
AMAKAEPHVN LMAVEVYRPG LAQLLQQIER DEIPNIRVLR GDAMDVLENM
160 170 180 190 200
IEPESLTGVR VFFPDPWPKA RHHKRRLLQS PTFALIASRL KAGGVLHVAT
210 220 230 240 250
DHAEYAEAIA EAGNAEPLLT SLDWESPMTH ERPVTKFEDK AHQVGSAITE

LIWGKIRS
Length:258
Mass (Da):28,586
Last modified:September 5, 2006 - v1
Checksum:iCD758B30746B1F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA Translation: ABG96957.1

Genome annotation databases

EnsemblBacteriaiABG96957; ABG96957; RHA1_ro05176
KEGGirha:RHA1_ro05176

Similar proteinsi

Entry informationi

Entry nameiTRMB_RHOJR
AccessioniPrimary (citable) accession number: Q0S679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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