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Q0S679

- TRMB_RHOSR

UniProt

Q0S679 - TRMB_RHOSR

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901S-adenosyl-L-methionineUniRule annotation
    Binding sitei115 – 1151S-adenosyl-L-methionineUniRule annotation
    Binding sitei142 – 1421S-adenosyl-L-methionineUniRule annotation
    Active sitei165 – 1651By similarity
    Binding sitei165 – 1651S-adenosyl-L-methionineUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-5173-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:RHA1_ro05176
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258tRNA (guanine-N(7)-)-methyltransferasePRO_0000288211Add
    BLAST

    Proteomic databases

    PRIDEiQ0S679.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro05176.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0S679.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 2384Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0S679-1 [UniParc]FASTAAdd to Basket

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    MPETPLMRDN GPVNHADQDA PAVPEEGQTK DSKGSRLHPR VTSFRSRRGA    50
    LTVAQQESWD RQWPRIGADV SDHRLDAPSW FGRDAPLILE IGSGTGTATA 100
    AMAKAEPHVN LMAVEVYRPG LAQLLQQIER DEIPNIRVLR GDAMDVLENM 150
    IEPESLTGVR VFFPDPWPKA RHHKRRLLQS PTFALIASRL KAGGVLHVAT 200
    DHAEYAEAIA EAGNAEPLLT SLDWESPMTH ERPVTKFEDK AHQVGSAITE 250
    LIWGKIRS 258
    Length:258
    Mass (Da):28,586
    Last modified:September 5, 2006 - v1
    Checksum:iCD758B30746B1F02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96957.1.
    RefSeqiYP_705115.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG96957; ABG96957; RHA1_ro05176.
    GeneIDi4222727.
    KEGGirha:RHA1_ro05176.
    PATRICi23209297. VBIRhoJos26306_5228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG96957.1 .
    RefSeqi YP_705115.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0S679.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro05176.

    Proteomic databases

    PRIDEi Q0S679.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG96957 ; ABG96957 ; RHA1_ro05176 .
    GeneIDi 4222727.
    KEGGi rha:RHA1_ro05176.
    PATRICi 23209297. VBIRhoJos26306_5228.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci RJOS101510:GJJ1-5173-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiTRMB_RHOSR
    AccessioniPrimary (citable) accession number: Q0S679
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3