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Q0S649 (Q0S649_RHOSR) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:RHA1_ro05206
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG96987.1
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region260 – 2645ACP-binding By similarity HAMAP MF_01815

Sites

Active site1231 By similarity HAMAP MF_01815
Active site2591 By similarity HAMAP MF_01815
Active site2901 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q0S649 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: CC54428ABC89DD6D

FASTA33935,266
        10         20         30         40         50         60 
MGKQIATVAG GRQSALLGLG VYRPERVVTN DEICELIDSN DEWIQSRSGI RNRRFAAEDE 

        70         80         90        100        110        120 
NVVTMSIEAG RKAIEASGID PEQIGCVIVA TSTYLLLTPP AAAVVADALG TNGPGAFDLG 

       130        140        150        160        170        180 
GGCAGFCTAL TVASDLVRGG SVDYALVVGV EKMSITTDPT DRATRFIFGD GAGAVVVGKS 

       190        200        210        220        230        240 
DVAGIGPVEW GSDGAQADAI VQDLDWYEYI TTPGATRPYI KMAGTAVFRW AAFEMGKVAL 

       250        260        270        280        290        300 
RAIEKAGMSV DDLDAFVPHQ ANSRITEVIA RSMKLPENVP VSDDIAESGN TSAASVPLAM 

       310        320        330 
EEMLQSGATK PGDTALLLAF GAGLSYAAQV VTMPVLAKD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000431 Genomic DNA. Translation: ABG96987.1.
RefSeqYP_705145.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0S649.
SMRQ0S649. Positions 1-334.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0S649.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4222757.
GenomeReviewsGene locus RHA1_ro05206 in contig CP000431_GR.
KEGGrha:RHA1_ro05206.
PATRIC23209357. VBIRhoJos26306_5258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAATRIEND.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycRSP101510:RHA1_RO05206-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK11608.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0S649_RHOSR
AccessionPrimary (citable) accession number: Q0S649
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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