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Protein

Glucose-6-phosphate isomerase 1

Gene

pgi1

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 4 (pgi4), Glucose-6-phosphate isomerase 2 (pgi2), Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 3 (pgi3)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei355Proton donorUniRule annotation1
Active sitei386UniRule annotation1
Active sitei512UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciRJOS101510:G1G71-5545-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 1UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 1UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 1UniRule annotation
Short name:
PGI 1UniRule annotation
Phosphohexose isomerase 1UniRule annotation
Short name:
PHI 1UniRule annotation
Gene namesi
Name:pgi1UniRule annotation
Ordered Locus Names:RHA1_ro05567
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002526371 – 550Glucose-6-phosphate isomerase 1Add BLAST550

Proteomic databases

PRIDEiQ0S539

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro05567

Structurei

3D structure databases

ProteinModelPortaliQ0S539
SMRiQ0S539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261371
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0S539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDITGTAA WQKLRDHHAQ IQSVHLRELF EKDPARGQEL TVTAGDLYID
60 70 80 90 100
YSKHRIDRDT LGLLLELARS ADLEARRDAM FAGEHINTSE DRAVLHTALR
110 120 130 140 150
LPADASLVVD GQDVVADVHE VLDRMGDFTD RVRSGEWRGA TGERIKTVVN
160 170 180 190 200
IGIGGSDLGP VMVYRALRHY ADAGISVRFI SNVDPADLVR SLQGLDPATT
210 220 230 240 250
LFIVASKTFS TLETLTNATA ARRWLLGGLG LGNEAVAKHF VAVSTHADRV
260 270 280 290 300
AEFGIDTANM FGFWDWVGGR YSVDSAIGLS VMAAIGKERF AEFLAGFHAV
310 320 330 340 350
DEHFRTAPLE ENAPVLLGLI GLWYSNFFGA ESRAVLPYSN DLVRFAAYLQ
360 370 380 390 400
QLTMESNGKS VRADGTPVPT STGEIFWGEP GTNGQHAFYQ LLHQGTRLVP
410 420 430 440 450
SDFIGFGEPT DDLPTADGTG SMHDLLMSNF FAQTKVLAFG KTAEEIAAEG
460 470 480 490 500
TPEHLVPHKV MPGNRPSTTI LAPKLTPSVI GQLIALYEHQ VFVEGVVWGI
510 520 530 540 550
DSFDQWGVEL GKTQAVELQP VLTAAEEPAA QSDSSTDSLV RWYRRQRGRA
Length:550
Mass (Da):60,028
Last modified:September 5, 2006 - v1
Checksum:i20C5F1651E86995C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA Translation: ABG97347.1
RefSeqiWP_011597733.1, NC_008268.1

Genome annotation databases

EnsemblBacteriaiABG97347; ABG97347; RHA1_ro05567
GeneIDi4223118
KEGGirha:RHA1_ro05567
PATRICifig|101510.16.peg.5611

Similar proteinsi

Entry informationi

Entry nameiG6PI1_RHOJR
AccessioniPrimary (citable) accession number: Q0S539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 5, 2006
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health