Reviewed, UniProtKB/Swiss-Prot Q0S539 (G6PI1_RHOSR)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 1
      Short name=GPI 1
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 1
      Short name=PGI 1
    Phosphohexose isomerase 1
      Short name=PHI 1

Gene names

Name:	pgi1
Ordered Locus Names:	RHA1_ro05567

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Glucose-6-phosphate isomerase 1 HAMAP MF_00473		PRO_0000252637
Sites
	Active site	355	1	Proton donor By similarity
	Active site	386	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0S539-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 20C5F1651E86995C	FASTA	550	60,028
	10 20 30 40 50 60 MSSDITGTAA WQKLRDHHAQ IQSVHLRELF EKDPARGQEL TVTAGDLYID YSKHRIDRDT 70 80 90 100 110 120 LGLLLELARS ADLEARRDAM FAGEHINTSE DRAVLHTALR LPADASLVVD GQDVVADVHE 130 140 150 160 170 180 VLDRMGDFTD RVRSGEWRGA TGERIKTVVN IGIGGSDLGP VMVYRALRHY ADAGISVRFI 190 200 210 220 230 240 SNVDPADLVR SLQGLDPATT LFIVASKTFS TLETLTNATA ARRWLLGGLG LGNEAVAKHF 250 260 270 280 290 300 VAVSTHADRV AEFGIDTANM FGFWDWVGGR YSVDSAIGLS VMAAIGKERF AEFLAGFHAV 310 320 330 340 350 360 DEHFRTAPLE ENAPVLLGLI GLWYSNFFGA ESRAVLPYSN DLVRFAAYLQ QLTMESNGKS 370 380 390 400 410 420 VRADGTPVPT STGEIFWGEP GTNGQHAFYQ LLHQGTRLVP SDFIGFGEPT DDLPTADGTG 430 440 450 460 470 480 SMHDLLMSNF FAQTKVLAFG KTAEEIAAEG TPEHLVPHKV MPGNRPSTTI LAPKLTPSVI 490 500 510 520 530 540 GQLIALYEHQ VFVEGVVWGI DSFDQWGVEL GKTQAVELQP VLTAAEEPAA QSDSSTDSLV 550 RWYRRQRGRA

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG97347.1.
RefSeq	YP_705505.1.
3D structure databases
SMR	Q0S539. Positions 3-548.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0S539.
Genome annotation databases
GeneID	4223118.
GenomeReviews	Gene locus RHA1_ro05567 in contig CP000431_GR.
KEGG	rha:RHA1_ro05567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	PARETIV.
PhylomeDB	Q0S539.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO05567-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI1_RHOSR

Accession

Primary (citable) accession number: Q0S539

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	September 5, 2006
Last modified:	January 19, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)