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Q0S4F9 (ACDH4_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 4

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 4
Gene names
Ordered Locus Names:RHA1_ro05800
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Acetaldehyde dehydrogenase 4 HAMAP-Rule MF_01657
PRO_0000387729

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding157 – 1659NAD By similarity

Sites

Active site1261Acyl-thioester intermediate By similarity
Binding site2761NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0S4F9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 118B1058DB8112FA

FASTA30031,462
        10         20         30         40         50         60 
MTKALAAIVG SGNIGTDLLY KLLRSEIIEP RWMIGVDPDS EGLKRAADRG VIASAEGVDW 

        70         80         90        100        110        120 
LLAQDERPDI VFEATSAYVH RANAPRYREL GIQAVDLTPA ALGPAVVPAV NMGEHRTAPN 

       130        140        150        160        170        180 
VNLITCGGQA TIPMVYAVSR ITEVAYAEIV ASVASPSAGP GTRANIDEFT ITTSRGIETI 

       190        200        210        220        230        240 
GGAKKGKAII ILNPAEPPMF MKDTVFCSIP ADADRDAITA SIHDVAASVQ AYVPGYRLRA 

       250        260        270        280        290        300 
EPQFDDPTPI SGGLARVGIF LEVEGAGDFL PPYSGNLDIM TAAATKVGES FATQILGASV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000431 Genomic DNA. Translation: ABG97577.1.
RefSeqYP_705735.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0S4F9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro05800.

Proteomic databases

PRIDEQ0S4F9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG97577; ABG97577; RHA1_ro05800.
GeneID4223351.
KEGGrha:RHA1_ro05800.
PATRIC23210525. VBIRhoJos26306_5838.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
OMAAYVHRAN.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-5797-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH4_RHOSR
AccessionPrimary (citable) accession number: Q0S4F9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families