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Protein

Acetaldehyde dehydrogenase 4

Gene

RHA1_ro05800

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126Acyl-thioester intermediateUniRule annotation1
Binding sitei276NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi157 – 165NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciRJOS101510:G1G71-5778-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 4UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 4UniRule annotation
Gene namesi
Ordered Locus Names:RHA1_ro05800
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877291 – 300Acetaldehyde dehydrogenase 4Add BLAST300

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro05800

Structurei

3D structure databases

ProteinModelPortaliQ0S4F9
SMRiQ0S4F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiGEHRTAP
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q0S4F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKALAAIVG SGNIGTDLLY KLLRSEIIEP RWMIGVDPDS EGLKRAADRG
60 70 80 90 100
VIASAEGVDW LLAQDERPDI VFEATSAYVH RANAPRYREL GIQAVDLTPA
110 120 130 140 150
ALGPAVVPAV NMGEHRTAPN VNLITCGGQA TIPMVYAVSR ITEVAYAEIV
160 170 180 190 200
ASVASPSAGP GTRANIDEFT ITTSRGIETI GGAKKGKAII ILNPAEPPMF
210 220 230 240 250
MKDTVFCSIP ADADRDAITA SIHDVAASVQ AYVPGYRLRA EPQFDDPTPI
260 270 280 290 300
SGGLARVGIF LEVEGAGDFL PPYSGNLDIM TAAATKVGES FATQILGASV
Length:300
Mass (Da):31,462
Last modified:September 5, 2006 - v1
Checksum:i118B1058DB8112FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA Translation: ABG97577.1
RefSeqiWP_011597908.1, NC_008268.1

Genome annotation databases

EnsemblBacteriaiABG97577; ABG97577; RHA1_ro05800
GeneIDi4223351
KEGGirha:RHA1_ro05800
PATRICifig|101510.16.peg.5838

Entry informationi

Entry nameiACDH4_RHOJR
AccessioniPrimary (citable) accession number: Q0S4F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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