Q0S4A2 (COAA_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	RHA1_ro05857

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Pantothenate kinase HAMAP MF_00215		PRO_1000043246
Regions
	Nucleotide binding	95 – 102	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0S4A2 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 4065997009AE9ABA	FASTA	310	35,538
	10 20 30 40 50 60 MARTSESSPY VEFDRKQWRT LRKSTPLVLT EEELYGLRGL GEQIDLEEVA EVYLPLSRLI 70 80 90 100 110 120 HLQVAARQRL FAATATFLGE KHPDQQVPFV IGVAGSVAVG KSTTARVLQA LLARWEHHPR 130 140 150 160 170 180 VDLVTTDGFL YPTAELNRRG IMHRKGFPES YDRRKLLRFV TEVKSGAEEV AAPVYSHISY 190 200 210 220 230 240 DIIPGQYHLI RQPDILIIEG LNVLQTGPRL MVSDLFDFSI YVDARIEDIE NWYIQRFLAL 250 260 270 280 290 300 RKTSFSDPDA HFHHYAGLSD RDATAAAQEI WHNINRPNLV ENILPTRPRA TLVLRKDANH 310 SINRLRLRKL

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RHA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG97634.1.
RefSeq	YP_705792.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0S4A2.
SMR	Q0S4A2. Positions 5-310.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0S4A2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4223408.
GenomeReviews	Gene locus RHA1_ro05857 in contig CP000431_GR.
KEGG	rha:RHA1_ro05857.
PATRIC	23210645. VBIRhoJos26306_5898.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q0S4A2.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO05857-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_RHOSR

Accession

Primary (citable) accession number: Q0S4A2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program