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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Rhodococcus jostii (strain RHA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-6013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
Ordered Locus Names:RHA1_ro06016Imported
OrganismiRhodococcus jostii (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ0S3U3.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro06016.

Structurei

3D structure databases

ProteinModelPortaliQ0S3U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S3U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKHHHHHRD VISPAYTGRL SIDPFPALRL PDEETDPEAA YRFIHDELML
60 70 80 90 100
DGSSRLNLAT FVTTWMDPEA DKLMAETFDK NMIDKDEYPA TAAIESRCVS
110 120 130 140 150
MVADLFHAPD LSTTDPASAT GVSTIGSSEA VMLGGLALKW LWRAKREAAG
160 170 180 190 200
KDTARPNLVL GSNVQVVWEK FCRYFDVEPK YLPMEKGRYV ITPEQVRDAV
210 220 230 240 250
DENTIGAVVI VGTTYTGELE PVAAIADALD ELAASGGPDV PIHVDAASGG
260 270 280 290 300
FVVPFLQPEL LWDFRVPRVA SINVSGHKYG LTYPGIGFVV WRDKEHLPEG
310 320 330 340 350
LVFRVNYLGG DMPTFTLNFS RPGNQVVGQY YNFLRLGRAG YRSIMQTLRD
360 370 380 390 400
TAVRVGKRIA EIEGFTLITD GTDIPVVAFE LVGDPGFTVF DVSHELRARG
410 420 430 440 450
WQVPAYTMPA DAEDVAVLRI VVREGFSADL GSLVAEAIEE VCAELREKGG
460
GRSTEQHFAH
Length:460
Mass (Da):50,627
Last modified:September 5, 2006 - v1
Checksum:i65A168B0681CF22F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG97793.1.
RefSeqiYP_705951.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG97793; ABG97793; RHA1_ro06016.
GeneIDi4223567.
KEGGirha:RHA1_ro06016.
PATRICi23210979. VBIRhoJos26306_6065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG97793.1.
RefSeqiYP_705951.1. NC_008268.1.

3D structure databases

ProteinModelPortaliQ0S3U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi101510.RHA1_ro06016.

Proteomic databases

PRIDEiQ0S3U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG97793; ABG97793; RHA1_ro06016.
GeneIDi4223567.
KEGGirha:RHA1_ro06016.
PATRICi23210979. VBIRhoJos26306_6065.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-6013-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1Imported.

Entry informationi

Entry nameiQ0S3U3_RHOJR
AccessioniPrimary (citable) accession number: Q0S3U3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.