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Q0S3C9

- Q0S3C9_RHOSR

UniProt

Q0S3C9 - Q0S3C9_RHOSR

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Protein

Alanine racemase

Gene

alr

Organism
Rhodococcus sp. (strain RHA1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei287 – 2871Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei335 – 3351Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-6177-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:RHA1_ro06180Imported
OrganismiRhodococcus sp. (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ0S3C9.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro06180.

Structurei

3D structure databases

ProteinModelPortaliQ0S3C9.
SMRiQ0S3C9. Positions 28-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S3C9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLAEAVPAD DHGHSEPAAP TQAPAPQAEA VVDLDAIAHN VRILRDSARD
60 70 80 90 100
AAMMAVVKAD GYNHGAVPVA RAALAAGASE LGVTTVSEAL TLRRAGIDAP
110 120 130 140 150
VLAWLHTVDA DFAPAIAAGV ELGVSSPRHL AAVVAAARSV GTTAIVTIKV
160 170 180 190 200
DTGLNRNGVA PDELAQVLVD LARAQAEGSV RLRGIFSHLA HADEPHHAWI
210 220 230 240 250
DSQRDRLISA IADAKRQGLV PEVVHLSNSA ATLTRPDLRF DMVRPGIAIY
260 270 280 290 300
GLSPVPELGQ FGLRPAMTLR SRVALVKKVA AGEGVSYGHQ WVAPRDTTVA
310 320 330 340 350
LLPFGYADGL PRSLSGRFEV QLGAQRRPGI GRVCMDQVVV DLGPDGGGVR
360 370 380 390 400
EGDTAVFFGN GDLGEPNAQA WADELDTIHY EVVTGVRGRT VRSYVGGTGT
Length:400
Mass (Da):41,776
Last modified:September 5, 2006 - v1
Checksum:i6DD3A7C46876A760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG97957.1.
RefSeqiYP_706115.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG97957; ABG97957; RHA1_ro06180.
GeneIDi4223731.
KEGGirha:RHA1_ro06180.
PATRICi23211301. VBIRhoJos26306_6226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG97957.1 .
RefSeqi YP_706115.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0S3C9.
SMRi Q0S3C9. Positions 28-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro06180.

Proteomic databases

PRIDEi Q0S3C9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG97957 ; ABG97957 ; RHA1_ro06180 .
GeneIDi 4223731.
KEGGi rha:RHA1_ro06180.
PATRICi 23211301. VBIRhoJos26306_6226.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci RJOS101510:GJJ1-6177-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1Imported.

Entry informationi

Entry nameiQ0S3C9_RHOSR
AccessioniPrimary (citable) accession number: Q0S3C9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3