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Q0S3A7 (Q0S3A7_RHOSR) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344
EC=6.3.5.2 HAMAP MF_00344
Alternative name(s):
GMP synthetase HAMAP MF_00344
Glutamine amidotransferase HAMAP MF_00344
Gene names
Name:guaA HAMAP MF_00344
Ordered Locus Names:RHA1_ro06202
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG97979.1
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344

Subunit structure

Homodimer By similarity. HAMAP MF_00344

Sequence similarities

Contains 1 GMP-binding domain. HAMAP MF_00344

Contains 1 glutamine amidotransferase type-1 domain. HAMAP MF_00344

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain9 – 198190Glutamine amidotransferase type-1 By similarity HAMAP MF_00344
Domain230 – 398169GMP-binding By similarity HAMAP MF_00344
Nucleotide binding226 – 2327ATP By similarity HAMAP MF_00344

Sites

Active site861Nucleophile By similarity HAMAP MF_00344
Active site1721 By similarity HAMAP MF_00344
Active site1741 By similarity HAMAP MF_00344

Sequences

Sequence LengthMass (Da)Tools
Q0S3A7 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 11694134CB922A9E

FASTA52355,722
        10         20         30         40         50         60 
MADIEQQRPV LVVDFGAQYA QLIARRVREA KVYSEVVPHT ATVEEIAAKN PLAVVLSGGP 

        70         80         90        100        110        120 
SSVYADGAPQ LDPALFDLDI PVFGICYGFQ AMAGALGGTV AHTGTREYGR TDLKVQGGLL 

       130        140        150        160        170        180 
HEGLPASQPV WMSHGDAVTE APAGFEVTAT SEGAPVAAFE DRARKLAGVQ YHPEVLHSPH 

       190        200        210        220        230        240 
GQQVLSRFLH EIAGIPPAWT AANIADALVE QVREQVGDGK AICGLSGGVD SAVAAALVQR 

       250        260        270        280        290        300 
AIGDNLTCVF VDHGLMRAGE RAQVEQDFVA ATGAKLITVD AADTFIGELA GVSDPETKRK 

       310        320        330        340        350        360 
IIGREFIRSF EGAVSDVLGE NAAHGDTVEF LVQGTLYPDV VESGGGTGTA NIKSHHNVGG 

       370        380        390        400        410        420 
LPEDLQFTLV EPLRLLFKDE VRAVGRELGL PEEIVGRQPF PGPGLGIRII GEVTQDRLDI 

       430        440        450        460        470        480 
LRHADSIARE ELTAAGLDGQ IWQCPVVLLA DVRSVGVQGD GRTYGHPIVL RPVSSEDAMT 

       490        500        510        520 
ADWTRLPYDV LERISTRITN EVHDVNRVVL DITSKPPGTI EWE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000431 Genomic DNA. Translation: ABG97979.1.
RefSeqYP_706137.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0S3A7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0S3A7.

Protein family/group databases

MEROPSC26.A17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4223753.
GenomeReviewsGene locus RHA1_ro06202 in contig CP000431_GR.
KEGGrha:RHA1_ro06202.
PATRIC23211347. VBIRhoJos26306_6249.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0519.
HOGENOMHBG391775.
OMADGRTYEY.
ProtClustDBPRK00074.

Enzyme and pathway databases

BioCycRSP101510:RHA1_RO06202-MONOMER.

Family and domain databases

HAMAPMF_00344. GMP_synthase.
[Tree]
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0S3A7_RHOSR
AccessionPrimary (citable) accession number: Q0S3A7
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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