Q0S358 (Q0S358_RHOSR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add2 EMBL ABG98028.1
Synonyms:	add HAMAP MF_00540
Ordered Locus Names:	RHA1_ro06251

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG98028.1

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540
Ligand	Metal-binding HAMAP MF_00540 Zinc HAMAP MF_00540
Molecular function	Hydrolase HAMAP MF_00540 EMBL ABG98028.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	210	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	18	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	20	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	207	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	299	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	20	1	Substrate By similarity HAMAP MF_00540
	Binding site	22	1	Substrate By similarity HAMAP MF_00540
	Binding site	180	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	231	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	Q0S358 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 8E5B127331BCCAE8	FASTA	361	39,611
	10 20 30 40 50 60 MTALDLSALR RAPKVLLHDH LDGGLRPETV LELARDCGYD ALPADTAPAL ATWFREAADS 70 80 90 100 110 120 GSLERYLETF AHTVAVMQTP VGLERVAREC AEDLAADGVV YAEVRFAPEQ HLEEGLTLDE 130 140 150 160 170 180 VVEQVLLGFE AGESAAEVRG QNIRIGVLLT AMRHAARSRE IAELAIRFRD RGVVGFDIAG 190 200 210 220 230 240 AEAGNPPSRH LDAFEYMRGS NAHFTIHAGE AFGLPSIHEA IAFCGTDRLG HGVRITDDIT 250 260 270 280 290 300 IGDDGVPVLG KLANYVRDKR IPLELCPSSN VQTGAVDALE NHPFDLLARL RFRVTVNTDN 310 320 330 340 350 360 RLMSDTSMSM EMLRLVETFG YGWTDLERYT INAMKSAFIP FDQRLQLIDE VIKPGFAVLV G

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG98028.1.
RefSeq	YP_706186.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0S358.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0S358.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4223802.
GenomeReviews	Gene locus RHA1_ro06251 in contig CP000431_GR.
KEGG	rha:RHA1_ro06251.
PATRIC	23211447. VBIRhoJos26306_6299.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	PYYMAMN.
PhylomeDB	Q0S358.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO06251-MONOMER.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0S358_RHOSR

Accession

Primary (citable) accession number: Q0S358

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)