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Q0S208

- PNP_RHOSR

UniProt

Q0S208 - PNP_RHOSR

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, RHA1_ro06655
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi532 – 5321Magnesium By similarity
Metal bindingi538 – 5381Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-6652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:RHA1_ro06655
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329806Add
BLAST

Proteomic databases

PRIDEiQ0S208.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro06655.

Structurei

3D structure databases

ProteinModelPortaliQ0S208.
SMRiQ0S208. Positions 16-732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini598 – 65760KH
Add
BLAST
Domaini669 – 73870S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0S208-1 [UniParc]FASTAAdd to Basket

« Hide

MTENSAVEVD EGVFESTAVI DNGSFGTRTI RFETGRLAQQ AAGAVVAYLD    50
DETMLLSATS ASKHPKEHFD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS 100
TDAILTCRLI DRPLRPSFVD GLRNEIQVVV TVMSLNPQDL YDVVAINAAS 150
ASTQIAGLPF SGPVGGVRVA LITSDENKAG QWVAFPTVEQ LENAVFDMVV 200
AGRIVSGSGD DADVAIMMVE AEATDNVISL IDGGAQAPTE AIVAEGLEAA 250
KPFIARLCTA QQQLAAKASK PTGDFPVFPA YQDDVFAAVE AAAAEKLSAA 300
LTIAGKQERD DKTDEVKVEV LEQVAPNFEG REKELGAAFR SLTKKLVRQR 350
ILRDQFRIDG RGITDIRSLS AEVAIVPRAH GSALFERGET QILGVTTLDM 400
VKMAQQVDSL GPETTKRYMH HYNFPPYSTG ETGRVGSPKR REIGHGALAE 450
RALMPVLPSV EEFPYAIRQV SEALSSNGST SMGSVCASTL ALLNAGVPLK 500
APVAGIAMGL VSDQVDGETR YVALTDILGA EDAFGDMDFK VAGTKDFVTA 550
LQLDTKLDGI PSKVLAGALS QAKDARATIL EVMAEAIDTP DEMSPFAPRV 600
TAIKVPVDKI GEVIGPKGKM INSITEQTGA NISIEDDGTV FVGATDGPSA 650
QAAIDMINAI ANPQLPKVGE RFLGTVVKTT AFGAFVSLLP GRDGLVHISK 700
LGSGKRIAKV EDVVSVGSKL RVEIADIDNR GKISLIPVEE DGAAAPAEQS 750
EEAAAEK 757
Length:757
Mass (Da):80,229
Last modified:September 5, 2006 - v1
Checksum:i3A31562C63CB7433
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG98428.1.
RefSeqiYP_706586.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG98428; ABG98428; RHA1_ro06655.
GeneIDi4224206.
KEGGirha:RHA1_ro06655.
PATRICi23212287. VBIRhoJos26306_6715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG98428.1 .
RefSeqi YP_706586.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0S208.
SMRi Q0S208. Positions 16-732.
ModBasei Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro06655.

Proteomic databases

PRIDEi Q0S208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG98428 ; ABG98428 ; RHA1_ro06655 .
GeneIDi 4224206.
KEGGi rha:RHA1_ro06655.
PATRICi 23212287. VBIRhoJos26306_6715.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-6652-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiPNP_RHOSR
AccessioniPrimary (citable) accession number: Q0S208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi