ID   Q0S193_RHOJR            Unreviewed;       530 AA.
AC   Q0S193;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=HD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=RHA1_ro06927 {ECO:0000313|EMBL:ABG98693.1};
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG98693.1, ECO:0000313|Proteomes:UP000008710};
RN   [1] {ECO:0000313|Proteomes:UP000008710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
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DR   EMBL; CP000431; ABG98693.1; -; Genomic_DNA.
DR   RefSeq; WP_011598664.1; NC_008268.1.
DR   AlphaFoldDB; Q0S193; -.
DR   KEGG; rha:RHA1_ro06927; -.
DR   PATRIC; fig|101510.16.peg.6989; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   OrthoDB; 9802066at2; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008710}.
FT   DOMAIN          262..458
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          452..518
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   530 AA;  57213 MW;  79AE8149572E4FEB CRC64;
     MHPHGTLPGS GKGLSRAELL AAVSLAIDLG LGQPMEHMLR SSLIATRIAE RMGLDPEQQA
     TVYYANLVGW IGCHADSHEL SALFGDDIAF RADTYAVDMT GLPFLRLMTS HVGRGLPGWE
     RGIRAAVFLV AARGRVATLI HSHCSSAGVL SDRMGLDGQV GKALAYVFER WDGRGLPNGC
     RGEGIPIEIH ISHVADVVEV HLRTGGLGHA KEVLRSRRGS QFSPAVVEVF ERDAAAIVDG
     LLEMDVWVAA LARAPDRDRT LTAEESDELL GAMADFVDLK SPFTLGHSRG VANLVAGAAR
     HLGMSPSDIT HLYRAGLVHS LGKMGVSNQI WEKKGPLTTT EWERVRMYPD LTGRILSRVN
     GLESVVSVAM KHRERIDGSG FPRGIAGAEL TAKDRLLAAA DAYQRLLEPR PHRLALDPRG
     AADRLKEEAR TGRLDAESVA AVLAAAGQRV SRRTPWPAGL TDREVEILRL VAQGRSNREI
     AADLFIAEKT ARNHVERVYA KLGVNNRTQA SLAAIDRGLV GFPVNAVVGK
//