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Q0S0K1 (Q0S0K1_RHOSR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP-Rule MF_00178
Short name=DMRL synthase HAMAP-Rule MF_00178
Short name=LS HAMAP-Rule MF_00178
Short name=Lumazine synthase HAMAP-Rule MF_00178
EC=2.5.1.78 HAMAP-Rule MF_00178
Gene names
Name:ribH HAMAP-Rule MF_00178 EMBL ABG98935.1
Ordered Locus Names:RHA1_ro07171 EMBL ABG98935.1
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG98935.1
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus ›

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity. HAMAP-Rule MF_00178 SAAS SAAS002180

Catalytic activity

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate. HAMAP-Rule MF_00178 SAAS SAAS002180 RuleBase RU003795

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2. HAMAP-Rule MF_00178 SAAS SAAS002180 RuleBase RU003795

Sequence similarities

Belongs to the DMRL synthase family. HAMAP-Rule MF_00178 RuleBase RU003795

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region58 – 6035-amino-6-(D-ribitylamino)uracil binding By similarity HAMAP-Rule MF_00178
Region80 – 8235-amino-6-(D-ribitylamino)uracil binding By similarity HAMAP-Rule MF_00178
Region85 – 8621-deoxy-L-glycero-tetrulose 4-phosphate binding By similarity HAMAP-Rule MF_00178

Sites

Active site881Proton donor By similarity HAMAP-Rule MF_00178
Binding site2615-amino-6-(D-ribitylamino)uracil By similarity HAMAP-Rule MF_00178
Binding site11315-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00178
Binding site12711-deoxy-L-glycero-tetrulose 4-phosphate By similarity HAMAP-Rule MF_00178

Sequences

Sequence LengthMass (Da)Tools
Q0S0K1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 62EFADF714361E28

FASTA16316,694
        10         20         30         40         50         60 
MSGEGLPELQ LGEAGDLRLA IVAGSWHAEI SEALIAGAQR VAAEANVKNV TLVRVAGAIE 

        70         80         90        100        110        120 
LPVVAQALAR THDAVVALGV VIRGGTPHFE YVCDAVTAGL TRVSLDESTP VGNGVLTTDT 

       130        140        150        160 
EQQAVDRSGL PGSVEDKGGQ ACAAALDTAV TLARLRRAEE SFV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000431 Genomic DNA. Translation: ABG98935.1.
RefSeqYP_707093.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0S0K1.
SMRQ0S0K1. Positions 13-138.
ModBaseSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro07171.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG98935; ABG98935; RHA1_ro07171.
GeneID4224721.
KEGGrha:RHA1_ro07171.
PATRIC23213321. VBIRhoJos26306_7225.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0054.
HOGENOMHOG000229253.
KOK00794.
OMAIVSMESA.
ProtClustDBPRK00061.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-7167-MONOMER.
UniPathwayUPA00275; UER00404.

Family and domain databases

Gene3D3.40.50.960. 1 hit.
HAMAPMF_00178. Lumazine_synth.
InterProIPR002180. DMRL_synthase.
[Graphical view]
PANTHERPTHR21058. PTHR21058. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0S0K1_RHOSR
AccessionPrimary (citable) accession number: Q0S0K1
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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