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Q0S005

- ACDH5_RHOSR

UniProt

Q0S005 - ACDH5_RHOSR

Protein

Acetaldehyde dehydrogenase 5

Gene

RHA1_ro08084

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
    Binding sitei297 – 2971NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi164 – 1729NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-7363-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 5UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 5UniRule annotation
    Gene namesi
    Ordered Locus Names:RHA1_ro08084
    Encoded oniPlasmid pRHL10 Publication
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Plasmid pRHL1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Acetaldehyde dehydrogenase 5PRO_0000387730Add
    BLAST

    Proteomic databases

    PRIDEiQ0S005.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro08084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0S005.
    SMRiQ0S005. Positions 6-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0S005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENTRKVTV AVIGSGNIGT DLMIKVIRHS EVLQMGAMVG IDPDSDGLAR    50
    ARRLGVPTTS DGVQGLLQLP NFDEIDVIFD ATSAKAHEAN AALLEPLGKR 100
    LIDLTPAALG PFVVPAVNLD EHRDAANVNM VTCGGQATIP IVAAVSRVTP 150
    VAYAEIVASI ASKSAGPGTR ANIDEFTETT SHAIETVGGA RRGKAIIILN 200
    PADPPLIMRD TVLCLISAPD PATHDAIRDS IQTMVDHVAT YVPGYRLKQQ 250
    VQITPVPDGQ PVRTLLASGD AATPTHQVSV FLEVEGAAHY LPAYAGNLDI 300
    MTSAAVRYAE SVADTIAAPT AAQGATR 327
    Length:327
    Mass (Da):34,131
    Last modified:September 5, 2006 - v1
    Checksum:iF6E755D4DC6726B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000432 Genomic DNA. Translation: ABG99131.1.
    RefSeqiYP_707289.1. NC_008269.1.

    Genome annotation databases

    EnsemblBacteriaiABG99131; ABG99131; RHA1_ro08084.
    GeneIDi4225209.
    KEGGirha:RHA1_ro08084.
    PATRICi23213724. VBIRhoJos26306_7426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000432 Genomic DNA. Translation: ABG99131.1 .
    RefSeqi YP_707289.1. NC_008269.1.

    3D structure databases

    ProteinModelPortali Q0S005.
    SMRi Q0S005. Positions 6-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro08084.

    Proteomic databases

    PRIDEi Q0S005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG99131 ; ABG99131 ; RHA1_ro08084 .
    GeneIDi 4225209.
    KEGGi rha:RHA1_ro08084.
    PATRICi 23213724. VBIRhoJos26306_7426.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci RJOS101510:GJJ1-7363-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiACDH5_RHOSR
    AccessioniPrimary (citable) accession number: Q0S005
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3