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Q0S005 (ACDH5_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 5

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 5
Gene names
Ordered Locus Names:RHA1_ro08084
Encoded onPlasmid pRHL1
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Acetaldehyde dehydrogenase 5 HAMAP-Rule MF_01657
PRO_0000387730

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding164 – 1729NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2971NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0S005 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: F6E755D4DC6726B5

FASTA32734,131
        10         20         30         40         50         60 
MSENTRKVTV AVIGSGNIGT DLMIKVIRHS EVLQMGAMVG IDPDSDGLAR ARRLGVPTTS 

        70         80         90        100        110        120 
DGVQGLLQLP NFDEIDVIFD ATSAKAHEAN AALLEPLGKR LIDLTPAALG PFVVPAVNLD 

       130        140        150        160        170        180 
EHRDAANVNM VTCGGQATIP IVAAVSRVTP VAYAEIVASI ASKSAGPGTR ANIDEFTETT 

       190        200        210        220        230        240 
SHAIETVGGA RRGKAIIILN PADPPLIMRD TVLCLISAPD PATHDAIRDS IQTMVDHVAT 

       250        260        270        280        290        300 
YVPGYRLKQQ VQITPVPDGQ PVRTLLASGD AATPTHQVSV FLEVEGAAHY LPAYAGNLDI 

       310        320 
MTSAAVRYAE SVADTIAAPT AAQGATR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000432 Genomic DNA. Translation: ABG99131.1.
RefSeqYP_707289.1. NC_008269.1.

3D structure databases

ProteinModelPortalQ0S005.
SMRQ0S005. Positions 6-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro08084.

Proteomic databases

PRIDEQ0S005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG99131; ABG99131; RHA1_ro08084.
GeneID4225209.
KEGGrha:RHA1_ro08084.
PATRIC23213724. VBIRhoJos26306_7426.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAFTETTAH.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-7363-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH5_RHOSR
AccessionPrimary (citable) accession number: Q0S005
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families