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Q0S005

- ACDH5_RHOJR

UniProt

Q0S005 - ACDH5_RHOJR

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Protein

Acetaldehyde dehydrogenase 5

Gene

RHA1_ro08084

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
Binding sitei297 – 2971NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NADUniRule annotation
Nucleotide bindingi164 – 1729NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-7363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 5UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 5UniRule annotation
Gene namesi
Ordered Locus Names:RHA1_ro08084
Encoded oniPlasmid pRHL10 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Plasmid pRHL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Acetaldehyde dehydrogenase 5PRO_0000387730Add
BLAST

Proteomic databases

PRIDEiQ0S005.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro08084.

Structurei

3D structure databases

ProteinModelPortaliQ0S005.
SMRiQ0S005. Positions 6-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S005-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENTRKVTV AVIGSGNIGT DLMIKVIRHS EVLQMGAMVG IDPDSDGLAR
60 70 80 90 100
ARRLGVPTTS DGVQGLLQLP NFDEIDVIFD ATSAKAHEAN AALLEPLGKR
110 120 130 140 150
LIDLTPAALG PFVVPAVNLD EHRDAANVNM VTCGGQATIP IVAAVSRVTP
160 170 180 190 200
VAYAEIVASI ASKSAGPGTR ANIDEFTETT SHAIETVGGA RRGKAIIILN
210 220 230 240 250
PADPPLIMRD TVLCLISAPD PATHDAIRDS IQTMVDHVAT YVPGYRLKQQ
260 270 280 290 300
VQITPVPDGQ PVRTLLASGD AATPTHQVSV FLEVEGAAHY LPAYAGNLDI
310 320
MTSAAVRYAE SVADTIAAPT AAQGATR
Length:327
Mass (Da):34,131
Last modified:September 5, 2006 - v1
Checksum:iF6E755D4DC6726B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000432 Genomic DNA. Translation: ABG99131.1.
RefSeqiYP_707289.1. NC_008269.1.

Genome annotation databases

EnsemblBacteriaiABG99131; ABG99131; RHA1_ro08084.
GeneIDi4225209.
KEGGirha:RHA1_ro08084.
PATRICi23213724. VBIRhoJos26306_7426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000432 Genomic DNA. Translation: ABG99131.1 .
RefSeqi YP_707289.1. NC_008269.1.

3D structure databases

ProteinModelPortali Q0S005.
SMRi Q0S005. Positions 6-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro08084.

Proteomic databases

PRIDEi Q0S005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG99131 ; ABG99131 ; RHA1_ro08084 .
GeneIDi 4225209.
KEGGi rha:RHA1_ro08084.
PATRICi 23213724. VBIRhoJos26306_7426.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-7363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiACDH5_RHOJR
AccessioniPrimary (citable) accession number: Q0S005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3