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Q0S005

- ACDH5_RHOSR

UniProt

Q0S005 - ACDH5_RHOSR

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Protein

Acetaldehyde dehydrogenase 5

Gene
RHA1_ro08084
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediate By similarity
Binding sitei297 – 2971NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-7363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 5 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 5
Gene namesi
Ordered Locus Names:RHA1_ro08084
Encoded oniPlasmid pRHL10 Publication
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Plasmid pRHL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Acetaldehyde dehydrogenase 5UniRule annotationPRO_0000387730Add
BLAST

Proteomic databases

PRIDEiQ0S005.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro08084.

Structurei

3D structure databases

ProteinModelPortaliQ0S005.
SMRiQ0S005. Positions 6-316.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0S005-1 [UniParc]FASTAAdd to Basket

« Hide

MSENTRKVTV AVIGSGNIGT DLMIKVIRHS EVLQMGAMVG IDPDSDGLAR    50
ARRLGVPTTS DGVQGLLQLP NFDEIDVIFD ATSAKAHEAN AALLEPLGKR 100
LIDLTPAALG PFVVPAVNLD EHRDAANVNM VTCGGQATIP IVAAVSRVTP 150
VAYAEIVASI ASKSAGPGTR ANIDEFTETT SHAIETVGGA RRGKAIIILN 200
PADPPLIMRD TVLCLISAPD PATHDAIRDS IQTMVDHVAT YVPGYRLKQQ 250
VQITPVPDGQ PVRTLLASGD AATPTHQVSV FLEVEGAAHY LPAYAGNLDI 300
MTSAAVRYAE SVADTIAAPT AAQGATR 327
Length:327
Mass (Da):34,131
Last modified:September 5, 2006 - v1
Checksum:iF6E755D4DC6726B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000432 Genomic DNA. Translation: ABG99131.1.
RefSeqiYP_707289.1. NC_008269.1.

Genome annotation databases

EnsemblBacteriaiABG99131; ABG99131; RHA1_ro08084.
GeneIDi4225209.
KEGGirha:RHA1_ro08084.
PATRICi23213724. VBIRhoJos26306_7426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000432 Genomic DNA. Translation: ABG99131.1 .
RefSeqi YP_707289.1. NC_008269.1.

3D structure databases

ProteinModelPortali Q0S005.
SMRi Q0S005. Positions 6-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro08084.

Proteomic databases

PRIDEi Q0S005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG99131 ; ABG99131 ; RHA1_ro08084 .
GeneIDi 4225209.
KEGGi rha:RHA1_ro08084.
PATRICi 23213724. VBIRhoJos26306_7426.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-7363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiACDH5_RHOSR
AccessioniPrimary (citable) accession number: Q0S005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi