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Q0RXC4

- ACDH6_RHOSR

UniProt

Q0RXC4 - ACDH6_RHOSR

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Protein

Acetaldehyde dehydrogenase 6

Gene
hpdG, RHA1_ro09018
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei125 – 1251Acyl-thioester intermediate By similarity
Binding sitei275 – 2751NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi156 – 1649NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-8297-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 6 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 6
Gene namesi
Name:hpdG
Ordered Locus Names:RHA1_ro09018
Encoded oniPlasmid pRHL10 Publication
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Plasmid pRHL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Acetaldehyde dehydrogenase 6UniRule annotationPRO_0000387731Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro09018.

Structurei

3D structure databases

ProteinModelPortaliQ0RXC4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RXC4-1 [UniParc]FASTAAdd to Basket

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MEPINAAIVG PGNIGTDLLA KLERVDSIAV QYVVGVVESD GLERARAKGI    50
SASAGGVDWL LEQDPLPEIV FEATSAKAHQ LNAPRYHELN IQAVDLTPAH 100
IGPMVCPPVN LTHHIDAPNV SMITCGGQAT IPMVHAVSRV SAVPYAEIVA 150
SVASRGAGPG TRANIDEFTQ TTGQAVSEVG GAARGRAIII LNPMEPPMIM 200
RDTVYCMIDA DADRDAISES VHRMVTEVQA YVPGYRLRAD PQFDDPKDGW 250
DGHGRVAIFL EVEGNGDYLP KYAGNLDIMT AAAARVGDSI ARNRMGVPA 299
Length:299
Mass (Da):31,708
Last modified:November 3, 2009 - v2
Checksum:iE0F9484669CC9144
GO

Sequence cautioni

The sequence ABH00062.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085906 Genomic DNA. Translation: BAB97164.1.
CP000432 Genomic DNA. Translation: ABH00062.1. Different initiation.
RefSeqiYP_708220.1. NC_008269.1.

Genome annotation databases

EnsemblBacteriaiABH00062; ABH00062; RHA1_ro09018.
GeneIDi4225923.
KEGGirha:RHA1_ro09018.
PATRICi23215476. VBIRhoJos26306_8301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085906 Genomic DNA. Translation: BAB97164.1 .
CP000432 Genomic DNA. Translation: ABH00062.1 . Different initiation.
RefSeqi YP_708220.1. NC_008269.1.

3D structure databases

ProteinModelPortali Q0RXC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro09018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH00062 ; ABH00062 ; RHA1_ro09018 .
GeneIDi 4225923.
KEGGi rha:RHA1_ro09018.
PATRICi 23215476. VBIRhoJos26306_8301.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-8297-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "2-Hydroxypenta-2,4-dienoate metabolic pathway genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1."
    Sakai M., Miyauchi K., Kato N., Masai E., Fukuda M.
    Appl. Environ. Microbiol. 69:427-433(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiACDH6_RHOSR
AccessioniPrimary (citable) accession number: Q0RXC4
Secondary accession number(s): Q8KZT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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