Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0RXC4

- ACDH6_RHOSR

UniProt

Q0RXC4 - ACDH6_RHOSR

Protein

Acetaldehyde dehydrogenase 6

Gene

hpdG

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei125 – 1251Acyl-thioester intermediateUniRule annotation
    Binding sitei275 – 2751NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi156 – 1649NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-8297-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 6UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 6UniRule annotation
    Gene namesi
    Name:hpdG
    Ordered Locus Names:RHA1_ro09018
    Encoded oniPlasmid pRHL10 Publication
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Plasmid pRHL1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Acetaldehyde dehydrogenase 6PRO_0000387731Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro09018.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0RXC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0RXC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPINAAIVG PGNIGTDLLA KLERVDSIAV QYVVGVVESD GLERARAKGI    50
    SASAGGVDWL LEQDPLPEIV FEATSAKAHQ LNAPRYHELN IQAVDLTPAH 100
    IGPMVCPPVN LTHHIDAPNV SMITCGGQAT IPMVHAVSRV SAVPYAEIVA 150
    SVASRGAGPG TRANIDEFTQ TTGQAVSEVG GAARGRAIII LNPMEPPMIM 200
    RDTVYCMIDA DADRDAISES VHRMVTEVQA YVPGYRLRAD PQFDDPKDGW 250
    DGHGRVAIFL EVEGNGDYLP KYAGNLDIMT AAAARVGDSI ARNRMGVPA 299
    Length:299
    Mass (Da):31,708
    Last modified:November 3, 2009 - v2
    Checksum:iE0F9484669CC9144
    GO

    Sequence cautioni

    The sequence ABH00062.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085906 Genomic DNA. Translation: BAB97164.1.
    CP000432 Genomic DNA. Translation: ABH00062.1. Different initiation.
    RefSeqiYP_708220.1. NC_008269.1.

    Genome annotation databases

    EnsemblBacteriaiABH00062; ABH00062; RHA1_ro09018.
    GeneIDi4225923.
    KEGGirha:RHA1_ro09018.
    PATRICi23215476. VBIRhoJos26306_8301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085906 Genomic DNA. Translation: BAB97164.1 .
    CP000432 Genomic DNA. Translation: ABH00062.1 . Different initiation.
    RefSeqi YP_708220.1. NC_008269.1.

    3D structure databases

    ProteinModelPortali Q0RXC4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro09018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABH00062 ; ABH00062 ; RHA1_ro09018 .
    GeneIDi 4225923.
    KEGGi rha:RHA1_ro09018.
    PATRICi 23215476. VBIRhoJos26306_8301.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci RJOS101510:GJJ1-8297-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "2-Hydroxypenta-2,4-dienoate metabolic pathway genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1."
      Sakai M., Miyauchi K., Kato N., Masai E., Fukuda M.
      Appl. Environ. Microbiol. 69:427-433(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiACDH6_RHOSR
    AccessioniPrimary (citable) accession number: Q0RXC4
    Secondary accession number(s): Q8KZT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3