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Protein

Acetaldehyde dehydrogenase 6

Gene

hpdG

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125Acyl-thioester intermediateUniRule annotation1
Binding sitei275NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 164NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 6UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 6UniRule annotation
Gene namesi
Name:hpdG
Ordered Locus Names:RHA1_ro09018
Encoded oniPlasmid pRHL10 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Plasmid pRHL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877311 – 299Acetaldehyde dehydrogenase 6Add BLAST299

Proteomic databases

PRIDEiQ0RXC4.

Structurei

3D structure databases

ProteinModelPortaliQ0RXC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RXC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPINAAIVG PGNIGTDLLA KLERVDSIAV QYVVGVVESD GLERARAKGI
60 70 80 90 100
SASAGGVDWL LEQDPLPEIV FEATSAKAHQ LNAPRYHELN IQAVDLTPAH
110 120 130 140 150
IGPMVCPPVN LTHHIDAPNV SMITCGGQAT IPMVHAVSRV SAVPYAEIVA
160 170 180 190 200
SVASRGAGPG TRANIDEFTQ TTGQAVSEVG GAARGRAIII LNPMEPPMIM
210 220 230 240 250
RDTVYCMIDA DADRDAISES VHRMVTEVQA YVPGYRLRAD PQFDDPKDGW
260 270 280 290
DGHGRVAIFL EVEGNGDYLP KYAGNLDIMT AAAARVGDSI ARNRMGVPA
Length:299
Mass (Da):31,708
Last modified:November 3, 2009 - v2
Checksum:iE0F9484669CC9144
GO

Sequence cautioni

The sequence ABH00062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085906 Genomic DNA. Translation: BAB97164.1.
CP000432 Genomic DNA. Translation: ABH00062.1. Different initiation.
RefSeqiWP_041813279.1. NC_008269.1.

Genome annotation databases

EnsemblBacteriaiABH00062; ABH00062; RHA1_ro09018.
GeneIDi4225923.
KEGGirha:RHA1_ro09018.
PATRICi23215476. VBIRhoJos26306_8301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085906 Genomic DNA. Translation: BAB97164.1.
CP000432 Genomic DNA. Translation: ABH00062.1. Different initiation.
RefSeqiWP_041813279.1. NC_008269.1.

3D structure databases

ProteinModelPortaliQ0RXC4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0RXC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABH00062; ABH00062; RHA1_ro09018.
GeneIDi4225923.
KEGGirha:RHA1_ro09018.
PATRICi23215476. VBIRhoJos26306_8301.

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH6_RHOJR
AccessioniPrimary (citable) accession number: Q0RXC4
Secondary accession number(s): Q8KZT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 2, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.