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Protein

Acetaldehyde dehydrogenase 7

Gene

RHA1_ro10116

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Acyl-thioester intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 13NADUniRule annotation4
Nucleotide bindingi159 – 167NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciRJOS101510:G1G71-8567-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 7UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 7UniRule annotation
Gene namesi
Ordered Locus Names:RHA1_ro10116
Encoded oniPlasmid pRHL20 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Plasmid pRHL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877321 – 262Acetaldehyde dehydrogenase 7Add BLAST262

Structurei

3D structure databases

ProteinModelPortaliQ0RWM7
SMRiQ0RWM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiCLIGDAD
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q0RWM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKVAIIGS GNIGTDLMFK IQRLSQTLEV AALVGIDPES DGLQRAGRLG
60 70 80 90 100
IPITADGVAG LLDIPGFDQI SIVFDATSAR AHVANAAALE PFGKQLVDLT
110 120 130 140 150
PAAIGPYVVP AVNLEENLAA RNVNMVTCGG QATIPMVAAV SHVAPVAYAE
160 170 180 190 200
IVASIASRSA GPGTRANIDE FTETTSKAIE VVGGAHRGKA IIVLNPADPP
210 220 230 240 250
LIMRDTILCL IGDADHDAIR DSVHRRVAEV SEYVPGYRLK QDVQITTVTD
260
DVPLSTLGRV SQ
Length:262
Mass (Da):27,348
Last modified:September 5, 2006 - v1
Checksum:iEC351AE6B1A07D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000433 Genomic DNA Translation: ABH00309.1
RefSeqiWP_011599978.1, NC_008270.1

Genome annotation databases

EnsemblBacteriaiABH00309; ABH00309; RHA1_ro10116
GeneIDi4226099
KEGGirha:RHA1_ro10116
PATRICifig|101510.16.peg.8524

Similar proteinsi

Entry informationi

Entry nameiACDH7_RHOJR
AccessioniPrimary (citable) accession number: Q0RWM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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