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Q0RWM7

- ACDH7_RHOSR

UniProt

Q0RWM7 - ACDH7_RHOSR

Protein

Acetaldehyde dehydrogenase 7

Gene

RHA1_ro10116

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 134NADUniRule annotation
    Nucleotide bindingi159 – 1679NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-8545-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 7UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 7UniRule annotation
    Gene namesi
    Ordered Locus Names:RHA1_ro10116
    Encoded oniPlasmid pRHL20 Publication
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Plasmid pRHL2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Acetaldehyde dehydrogenase 7PRO_0000387732Add
    BLAST

    Proteomic databases

    PRIDEiQ0RWM7.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro10116.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0RWM7.
    SMRiQ0RWM7. Positions 4-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    OMAiTVIHARV.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0RWM7-1 [UniParc]FASTAAdd to Basket

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    MTTKVAIIGS GNIGTDLMFK IQRLSQTLEV AALVGIDPES DGLQRAGRLG    50
    IPITADGVAG LLDIPGFDQI SIVFDATSAR AHVANAAALE PFGKQLVDLT 100
    PAAIGPYVVP AVNLEENLAA RNVNMVTCGG QATIPMVAAV SHVAPVAYAE 150
    IVASIASRSA GPGTRANIDE FTETTSKAIE VVGGAHRGKA IIVLNPADPP 200
    LIMRDTILCL IGDADHDAIR DSVHRRVAEV SEYVPGYRLK QDVQITTVTD 250
    DVPLSTLGRV SQ 262
    Length:262
    Mass (Da):27,348
    Last modified:September 5, 2006 - v1
    Checksum:iEC351AE6B1A07D09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000433 Genomic DNA. Translation: ABH00309.1.
    RefSeqiYP_708467.1. NC_008270.1.

    Genome annotation databases

    EnsemblBacteriaiABH00309; ABH00309; RHA1_ro10116.
    GeneIDi4226099.
    KEGGirha:RHA1_ro10116.
    PATRICi23215923. VBIRhoJos26306_8524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000433 Genomic DNA. Translation: ABH00309.1 .
    RefSeqi YP_708467.1. NC_008270.1.

    3D structure databases

    ProteinModelPortali Q0RWM7.
    SMRi Q0RWM7. Positions 4-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro10116.

    Proteomic databases

    PRIDEi Q0RWM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABH00309 ; ABH00309 ; RHA1_ro10116 .
    GeneIDi 4226099.
    KEGGi rha:RHA1_ro10116.
    PATRICi 23215923. VBIRhoJos26306_8524.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    OMAi TVIHARV.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci RJOS101510:GJJ1-8545-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiACDH7_RHOSR
    AccessioniPrimary (citable) accession number: Q0RWM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3