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Protein

2-phospho-L-lactate guanylyltransferase 2

Gene

cofC2

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:G1G71-8962-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferase 2UniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferase 2UniRule annotation
Gene namesi
Name:cofC2UniRule annotation
Ordered Locus Names:RHA1_ro11040
Encoded oniPlasmid pRHL30 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Plasmid pRHL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987081 – 2142-phospho-L-lactate guanylyltransferase 2Add BLAST214

Structurei

3D structure databases

SMRiQ0RVJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941
OMAiMARWCAV
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0RVJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYGEWAVI VPFRSLDVAK SRLAVSCRRD LALAFLQDTL AALTLSNHIS
60 70 80 90 100
SVIVVSRNAA LSETIGTPVI KDQGSGIDDA VEIGHRWLRE HGHDGHYSVV
110 120 130 140 150
MPDLPALRTG DIDNFLSAAS RFPRAFVADS AGTGTTCLTT QQAAILSAFG
160 170 180 190 200
RNSAQRHTRM GYKQIPLGLP SLRLDVDTID DLERAARMGV GRHTQRLLIS
210
NNELHSLRFP CAPG
Length:214
Mass (Da):23,243
Last modified:September 5, 2006 - v1
Checksum:iBB9ECCEF3CA90D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000434 Genomic DNA Translation: ABH00687.1
RefSeqiWP_011600315.1, NC_008271.1

Genome annotation databases

EnsemblBacteriaiABH00687; ABH00687; RHA1_ro11040
GeneIDi4226473
KEGGirha:RHA1_ro11040

Entry informationi

Entry nameiCOFC2_RHOJR
AccessioniPrimary (citable) accession number: Q0RVJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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