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Protein

2-phospho-L-lactate guanylyltransferase 2

Gene

cofC2

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-8927-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferase 2UniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferase 2UniRule annotation
Gene namesi
Name:cofC2UniRule annotation
Ordered Locus Names:RHA1_ro11040
Encoded oniPlasmid pRHL30 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Plasmid pRHL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2142142-phospho-L-lactate guanylyltransferase 2PRO_0000398708Add
BLAST

Proteomic databases

PRIDEiQ0RVJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639.
KOiK14941.
OMAiATWILIP.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RVJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYGEWAVI VPFRSLDVAK SRLAVSCRRD LALAFLQDTL AALTLSNHIS
60 70 80 90 100
SVIVVSRNAA LSETIGTPVI KDQGSGIDDA VEIGHRWLRE HGHDGHYSVV
110 120 130 140 150
MPDLPALRTG DIDNFLSAAS RFPRAFVADS AGTGTTCLTT QQAAILSAFG
160 170 180 190 200
RNSAQRHTRM GYKQIPLGLP SLRLDVDTID DLERAARMGV GRHTQRLLIS
210
NNELHSLRFP CAPG
Length:214
Mass (Da):23,243
Last modified:September 5, 2006 - v1
Checksum:iBB9ECCEF3CA90D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000434 Genomic DNA. Translation: ABH00687.1.
RefSeqiWP_011600315.1. NC_008271.1.

Genome annotation databases

EnsemblBacteriaiABH00687; ABH00687; RHA1_ro11040.
GeneIDi4226473.
KEGGirha:RHA1_ro11040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000434 Genomic DNA. Translation: ABH00687.1.
RefSeqiWP_011600315.1. NC_008271.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0RVJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABH00687; ABH00687; RHA1_ro11040.
GeneIDi4226473.
KEGGirha:RHA1_ro11040.

Phylogenomic databases

HOGENOMiHOG000223639.
KOiK14941.
OMAiATWILIP.
OrthoDBiPOG091H0B3J.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciRJOS101510:GJJ1-8927-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC2_RHOJR
AccessioniPrimary (citable) accession number: Q0RVJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.