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Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 4 (pgi4), Glucose-6-phosphate isomerase 2 (pgi2), Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 3 (pgi3)
  3. 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521Proton donorUniRule annotation
Active sitei383 – 3831UniRule annotation
Active sitei509 – 5091UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-8950-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 2UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 2UniRule annotation
Short name:
PGI 2UniRule annotation
Phosphohexose isomerase 2UniRule annotation
Short name:
PHI 2UniRule annotation
Gene namesi
Name:pgi2UniRule annotation
Ordered Locus Names:RHA1_ro11063
Encoded oniPlasmid pRHL30 Publication
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
ProteomesiUP000008710 Componenti: Plasmid pRHL3

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Glucose-6-phosphate isomerase 2PRO_0000252638Add
BLAST

Proteomic databases

PRIDEiQ0RVH6.

Structurei

3D structure databases

ProteinModelPortaliQ0RVH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0RVH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIVTDTPL WKKLSDHHWE VVGTHLRELF DTDPDRGVDL IVTAADLYID
60 70 80 90 100
YSKHRVTRET MGLLVDLARA AGVERHREAM FTGAHINTSE DRAVLHTALR
110 120 130 140 150
ANPERELIVD GQDVVGDVHT VLRRMGEFTD RVRSGAWRGA TGERIRTVVN
160 170 180 190 200
IGIGGSDLGP AMAYRALRHY VDGPEVRFVS NIDPADLLSN LTDLDPRTTL
210 220 230 240 250
FVVVSKTFST LETMTNASAA RRWITEALGE HAVPRHFVAV STDEERVTAF
260 270 280 290 300
GITARNIFGF WEWVGGRYSV GSAAGLSVMI AIGRERFTEF LGGMRAIDEH
310 320 330 340 350
FRTTPLESNA PVILGMLGVW YSSFFGADAR AVLPYAHDLA RFPAYLQQLT
360 370 380 390 400
MESNGKSVRT DGTPVGTFTG EIFWGEPGTN GQHAFHQLLH QGTHLIPVDF
410 420 430 440 450
LGFAEPIEDL PTLDGIGSVH DVLTANLFAQ SKVLAFGKNA DEVAADGTPS
460 470 480 490 500
ALVPHKVMSG NRPSTTILGA KLTPSTLGQL IALYEHQVFV QGIVWGIDSF
510 520 530 540 550
DQWGVELGKT SALELGPALW DLDGAAYVGD SSTTGLIRTY RLARGERRCL

P
Length:551
Mass (Da):60,350
Last modified:September 5, 2006 - v1
Checksum:iADE6DD98F743050C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000434 Genomic DNA. Translation: ABH00710.1.
RefSeqiWP_011600338.1. NC_008271.1.

Genome annotation databases

EnsemblBacteriaiABH00710; ABH00710; RHA1_ro11063.
GeneIDi4226496.
KEGGirha:RHA1_ro11063.
PATRICi23216664. VBIRhoJos26306_8894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000434 Genomic DNA. Translation: ABH00710.1.
RefSeqiWP_011600338.1. NC_008271.1.

3D structure databases

ProteinModelPortaliQ0RVH6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0RVH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABH00710; ABH00710; RHA1_ro11063.
GeneIDi4226496.
KEGGirha:RHA1_ro11063.
PATRICi23216664. VBIRhoJos26306_8894.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciRJOS101510:GJJ1-8950-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiG6PI2_RHOJR
AccessioniPrimary (citable) accession number: Q0RVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 5, 2006
Last modified: July 22, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.