Q0RUR2 (G6PI4_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase 4
Short name=GPI 4
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase 4
Short name=PGI 4
Phosphohexose isomerase 4
Short name=PHI 4

Gene names

Name:	pgi4
Ordered Locus Names:	RHA1_ro11327

Encoded on

Plasmid pRHL3

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Glucose-6-phosphate isomerase 4 HAMAP MF_00473		PRO_0000252640
Sites
	Active site	356	1	Proton donor By similarity
	Active site	387	1	By similarity
	Active site	513	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0RUR2 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: F420E63665A92866	FASTA	559	60,664
	10 20 30 40 50 60 MTAQHSDITA TSAWQKLHAH RDETSALTIR ELFAADTERG RELTLTAGEL YIDYSKQRVS 70 80 90 100 110 120 RHTLALLVEL ARAAGVEERR DAMFRGERIN TSEDRAVLHT ALRLPAHASL RVDGHDVVAD 130 140 150 160 170 180 VHRVLARMGV FSDRLRSGEW RGATGRPIMT VVNIGIGGSD LGPHMVYRAL RHYADSGISV 190 200 210 220 230 240 RFISNVDPSD LVATLADLDP STTLFIVASK TFSTLETLTN AANARRWVTS ALGEQAVARH 250 260 270 280 290 300 FVAVSTNAER VAAFGIDTEN MFGFWDWVGG RYSVGSAVGL AVMVAIGKDS FEEFLDGFHT 310 320 330 340 350 360 IDRHFADTPL EDNAPAILAL LGVWYSNFFG AETRAILPYS NDLGRFPAYL QQLAMESNGK 370 380 390 400 410 420 SVRADGSPIG TTTGAVFWGE PGSNGQHAFY QLLHQGTRLV PADFIGFAEP THDLPAADGA 430 440 450 460 470 480 GSMHNILMSN LFAQSRVLAF GKTPEELTRE DTAPDLIAHK TMPGNQPSTT ILAPRLTPSV 490 500 510 520 530 540 LGQLIALYEH QVFVEGIIYG IGSFDQWGVE LGKTQALELE PALSSGNGSL PSDLDSSTAS 550 MIRWYHGVRA HGTATVGRP

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RHA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000434 Genomic DNA. Translation: ABH00974.1.
RefSeq	YP_709132.1. NC_008271.1.
3D structure databases
ProteinModelPortal	Q0RUR2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0RUR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4226768.
GenomeReviews	Gene locus RHA1_ro11327 in contig CP000434_GR.
KEGG	rha:RHA1_ro11327.
PATRIC	23217146. VBIRhoJos26306_9135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	NINTTHI.
PhylomeDB	Q0RUR2.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO11327-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI4_RHOSR

Accession

Primary (citable) accession number: Q0RUR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program