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Q0RUP1 (Q0RUP1_FRAAA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAJ58692.1
Ordered Locus Names:FRAAL0009
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP] EMBL CAJ58692.1
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q0RUP1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: FCAF2DEEC6F22AA0

FASTA83492,098
        10         20         30         40         50         60 
MVDVLPPPPG DRIEPIGIEV EMQRSYLDYA MSVIVGRALP EVRDGLKPVH RRVLYAMYDG 

        70         80         90        100        110        120 
GYRPDRGYFK CSRVVGDVMG NYHPHGDSAI YDTLVRLAQP WSLRYPLVDG NGNFGSPGND 

       130        140        150        160        170        180 
PPAAMRYTEA RMAALAMEML RDIDQETVDF APNYDGRSQE PLVLPSRFPN LLVNGAGGIA 

       190        200        210        220        230        240 
VGMATNIPPH NLREVATGVQ WALDHAEATD EELLEALIGI IKGPDFPTSG LIVGRSGIED 

       250        260        270        280        290        300 
AYRTGRGSIR MRAVVNVEEN KGRTQLVVTE LPYQVNPDNL AEKIAELVRD NKVTGISDVR 

       310        320        330        340        350        360 
DETSARIGQR LVIDLKRDAV AKVVLNNLYK HTQLQDTFGV NMLAIVDGVP RTLRLDQMIR 

       370        380        390        400        410        420 
YYVEHQVDVI VRRTRYQLRK ARERLHVLDG LLIALDHLDE VISLIRNAES ADAARGQLME 

       430        440        450        460        470        480 
RFTLSEIQAT AILDMQLRRL AALERQRIID EAAELRARIS ELEAILASPV RQRQIIGEEL 

       490        500        510        520        530        540 
AEVVEKFGDE RRTRLVPFEG DMSIEDLIAQ EDVVVTVTRG GYAKRTKTDL YRSQRRGGKG 

       550        560        570        580        590        600 
VQGAALREDD IVEHFFVTTT HHWLLFFTNK GRVYRAKAHE LPEQARSAKG QHVANILAFS 

       610        620        630        640        650        660 
QDERIAEVIA LKDYEVAPYL VLATKRGLCK KTALSDFDSN RAGGLVAINL RDDDELIAAR 

       670        680        690        700        710        720 
LVAPGDDLLL VSRNAQSIRF HADDEQLRPM GRATSGVIGM RFDAEDELLS MDVVVPGTTA 

       730        740        750        760        770        780 
DLLVATSGGY AKRTPLAEYP VQGRGGKGVL TAKIVSTRGG LVGALVVDPD DQLYAIASNG 

       790        800        810        820        830 
GVLRTIAKDV RRAQRQTMGV RLIDLETGVQ VVGVARNADA EDTEAPTDPG AQES

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573213 Genomic DNA. Translation: CAJ58692.1.
RefSeqYP_710307.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0RUP1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0RUP1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4231189.
GenomeReviewsGene locus FRAAL0009 in contig CT573213_GR.
KEGGfal:FRAAL0009.
PATRIC21910063. VBIFraAln347_0006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHBG635183.
OMATGRGRIY.
PhylomeDBQ0RUP1.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0RUP1_FRAAA
AccessionPrimary (citable) accession number: Q0RUP1
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info