Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei203DesacetylmycothiolUniRule annotation1
Binding sitei242DesacetylmycothiolUniRule annotation1
Binding sitei261DesacetylmycothiolUniRule annotation1
Binding sitei299Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:FRAAL0935
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002551 – 333Mycothiol acetyltransferaseAdd BLAST333

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL0935.

Structurei

3D structure databases

ProteinModelPortaliQ0RS64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 170N-acetyltransferase 1UniRule annotationAdd BLAST153
Domaini176 – 333N-acetyltransferase 2UniRule annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 100Acetyl-CoA binding 1UniRule annotation3
Regioni265 – 267Acetyl-CoA binding 2UniRule annotation3
Regioni272 – 278Acetyl-CoA binding 2UniRule annotation7
Regioni304 – 309Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0RS64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGPYGRPV TASLTWQPTL SAADVDDIVS LLATAERADG TGPVSEDVRL
60 70 80 90 100
TLRPDQRVGA ARHLLAVSAT GVEASGPRRP IVGYAHLGGA LDSRQAEIVV
110 120 130 140 150
DPGHRGLGIG RALATALTEA LGDPPARLDV WAHGDLPPAA ALAARLGFAR
160 170 180 190 200
TRVLFQLRRP LGAVAPLPEP QLPAGVTVRA FVPGRDDEAW LAVNAAAFAD
210 220 230 240 250
HPEQGRWTLD DLALRRAEPW FDPRGFFVAE RDGQLVGFHW TKIHEVDETP
260 270 280 290 300
PPGTRPGPIG EVYVVGVLPG AGGAGLGRAL TLIGLRHLQA EGLAAVLLYV
310 320 330
DEDNERAVRM YTGLDFTVHT RDVSYHWRGA AAD
Length:333
Mass (Da):35,410
Last modified:September 5, 2006 - v1
Checksum:iF444FDD38E1CC5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ59601.1.
RefSeqiWP_011602165.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL0935.
PATRICi21911733. VBIFraAln347_0834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ59601.1.
RefSeqiWP_011602165.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RS64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL0935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL0935.
PATRICi21911733. VBIFraAln347_0834.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_FRAAA
AccessioniPrimary (citable) accession number: Q0RS64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.