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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei203DesacetylmycothiolUniRule annotation1
Binding sitei242DesacetylmycothiolUniRule annotation1
Binding sitei261DesacetylmycothiolUniRule annotation1
Binding sitei299Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciFALN326424:G1GJE-815-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:FRAAL0935
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002551 – 333Mycothiol acetyltransferaseAdd BLAST333

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL0935

Structurei

3D structure databases

ProteinModelPortaliQ0RS64
SMRiQ0RS64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 170N-acetyltransferase 1UniRule annotationAdd BLAST153
Domaini176 – 333N-acetyltransferase 2UniRule annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 100Acetyl-CoA binding 1UniRule annotation3
Regioni265 – 267Acetyl-CoA binding 2UniRule annotation3
Regioni272 – 278Acetyl-CoA binding 2UniRule annotation7
Regioni304 – 309Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV Bacteria
COG0456 LUCA
HOGENOMiHOG000248937
KOiK15520
OMAiAEPWFDP

Family and domain databases

HAMAPiMF_01698 MshD, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR017813 Mycothiol_AcTrfase
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 2 hits
PIRSFiPIRSF021524 MSH_acetyltransferase, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR03448 mycothiol_MshD, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q0RS64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGPYGRPV TASLTWQPTL SAADVDDIVS LLATAERADG TGPVSEDVRL
60 70 80 90 100
TLRPDQRVGA ARHLLAVSAT GVEASGPRRP IVGYAHLGGA LDSRQAEIVV
110 120 130 140 150
DPGHRGLGIG RALATALTEA LGDPPARLDV WAHGDLPPAA ALAARLGFAR
160 170 180 190 200
TRVLFQLRRP LGAVAPLPEP QLPAGVTVRA FVPGRDDEAW LAVNAAAFAD
210 220 230 240 250
HPEQGRWTLD DLALRRAEPW FDPRGFFVAE RDGQLVGFHW TKIHEVDETP
260 270 280 290 300
PPGTRPGPIG EVYVVGVLPG AGGAGLGRAL TLIGLRHLQA EGLAAVLLYV
310 320 330
DEDNERAVRM YTGLDFTVHT RDVSYHWRGA AAD
Length:333
Mass (Da):35,410
Last modified:September 5, 2006 - v1
Checksum:iF444FDD38E1CC5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA Translation: CAJ59601.1
RefSeqiWP_011602165.1, NC_008278.1

Genome annotation databases

KEGGifal:FRAAL0935

Similar proteinsi

Entry informationi

Entry nameiMSHD_FRAAA
AccessioniPrimary (citable) accession number: Q0RS64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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