Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q0RRU5 (Q0RRU5_FRAAA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL CAJ59720.1
Ordered Locus Names:FRAAL1055
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP] EMBL CAJ59720.1
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region115 – 12395-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2415-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9015-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1191Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q0RRU5 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 055D455E2811C50E

FASTA17718,666
        10         20         30         40         50         60 
MSDNAALAAR VRAASHLTGT FLLRSGRTST EYFDKYLFEA DPELLAAIVD GLTGLVPPGT 

        70         80         90        100        110        120 
DLLAGLELGG VPLATLLSQR TGLPARFVRK KAKEYGTRRI AEGGEVTGRR VVLVEDVVTS 

       130        140        150        160        170 
GGAVLDATKV LRDDGAIVED VLCVIDRGEG GRERLAELGL TLRPLLTRAE LDAAAAP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573213 Genomic DNA. Translation: CAJ59720.1.
RefSeqYP_711316.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0RRU5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0RRU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4237519.
GenomeReviewsGene locus FRAAL1055 in contig CT573213_GR.
KEGGfal:FRAAL1055.
PATRIC21911963. VBIFraAln347_0948.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMAQTCLVIN.
PhylomeDBQ0RRU5.
ProtClustDBCLSK2486794.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0RRU5_FRAAA
AccessionPrimary (citable) accession number: Q0RRU5
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info