Q0RRG0 (DEOC_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	FRAAL1197

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP]

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia › Frankia alni

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP-Rule MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP-Rule MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP-Rule MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro deoxyribose phosphate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Deoxyribose-phosphate aldolase HAMAP-Rule MF_00114		PRO_1000117545
Sites
	Active site	161	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	191	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0RRG0 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 5B6C00FDDBB6D614	FASTA	227	23,377
	10 20 30 40 50 60 MRRAEVARLI DHTLLAPAAT DEEVLALCAE AARLGVGAVC VAPTHVYLAA ASTYRSSHEA 70 80 90 100 110 120 EPAFAVASVI GFPHGTHLTV IKAEEARRAV ADGATEIDMV IDIANALDEN WRAIETEISE 130 140 150 160 170 180 VRLSVPPHVI LKVILETALL PDANIIAACR AAEAGGAEFV KTSTGFHPAG GASVRAVRAM 190 200 210 220 AEAVGGRLGI KASGGIRTAE KAKDMLEAGA TRLGLSASAD VLAGFPA

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACN14a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573213 Genomic DNA. Translation: CAJ59859.1.
RefSeq	YP_711452.1. NC_008278.1.
3D structure databases
ProteinModelPortal	Q0RRG0.
ModBase	Search...
Protein-protein interaction databases
STRING	326424.FRAAL1197.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4236457.
KEGG	fal:FRAAL1197.
PATRIC	21912233. VBIFraAln347_1080.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HOG000241645.
KO	K01619.
OMA	VCVAPTH.
ProtClustDB	CLSK947868.
Enzyme and pathway databases
BioCyc	FALN326424:GJ82-1177-MONOMER.
UniPathway	UPA00002; UER00468.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00114. DeoC_type1.
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/FbaB/lacD_aldolase. [Graphical view]
PANTHER	PTHR10889. PTHR10889. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_FRAAA

Accession

Primary (citable) accession number: Q0RRG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program