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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611Schiff-base intermediate with acetaldehydeUniRule annotation
Active sitei191 – 1911UniRule annotation

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB-HAMAP
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciFALN326424:GJ82-1177-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:FRAAL1197
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Deoxyribose-phosphate aldolasePRO_1000117545Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL1197.

Structurei

3D structure databases

ProteinModelPortaliQ0RRG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RRG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAEVARLI DHTLLAPAAT DEEVLALCAE AARLGVGAVC VAPTHVYLAA
60 70 80 90 100
ASTYRSSHEA EPAFAVASVI GFPHGTHLTV IKAEEARRAV ADGATEIDMV
110 120 130 140 150
IDIANALDEN WRAIETEISE VRLSVPPHVI LKVILETALL PDANIIAACR
160 170 180 190 200
AAEAGGAEFV KTSTGFHPAG GASVRAVRAM AEAVGGRLGI KASGGIRTAE
210 220
KAKDMLEAGA TRLGLSASAD VLAGFPA
Length:227
Mass (Da):23,377
Last modified:September 4, 2006 - v1
Checksum:i5B6C00FDDBB6D614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ59859.1.
RefSeqiWP_011602400.1. NC_008278.1.
YP_711452.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL1197.
PATRICi21912233. VBIFraAln347_1080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ59859.1.
RefSeqiWP_011602400.1. NC_008278.1.
YP_711452.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RRG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL1197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL1197.
PATRICi21912233. VBIFraAln347_1080.

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
BioCyciFALN326424:GJ82-1177-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiDEOC_FRAAA
AccessioniPrimary (citable) accession number: Q0RRG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2009
Last sequence update: September 4, 2006
Last modified: March 31, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.