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Q0RQV6 (MTNC_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Enolase-phosphatase E1
EC=3.1.3.77
Alternative name(s):
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Gene names
Name:mtnC
Ordered Locus Names:FRAAL1409
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP]
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) By similarity. HAMAP MF_01681

Catalytic activity

5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. HAMAP MF_01681

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01681

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. HAMAP MF_01681

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

Subunit structure

Monomer By similarity. HAMAP MF_01681

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Enolase-phosphatase E1 HAMAP MF_01681
PRO_0000357366

Sequences

Sequence LengthMass (Da)Tools
Q0RQV6 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 5933AC65ACCF5B41

FASTA23624,894
        10         20         30         40         50         60 
MSSPRPSAEL ALLDIEGTTS PTAAVLSSLF PYARARLGPW VRDHGDDPEV RRIVAEARSL 

        70         80         90        100        110        120 
LGEADAPVQR VVAALTRWSD DDRKVAPLKA LQGLIWAAGF AAGELTGELF DDVAPALRRW 

       130        140        150        160        170        180 
HAAGVRLAVF SSGSVLAQRA WFAATPAGDL TGLFDGYFDI DSAGPKRDPA AYRRIATELA 

       190        200        210        220        230 
VTPRRAVFLS DVSAELDAAS AAGFATVAVL RPGEPHHLAG NHPCVASFAE MAVDAA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573213 Genomic DNA. Translation: CAJ60067.1.
RefSeqYP_711657.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0RQV6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0RQV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4232578.
GenomeReviewsGene locus FRAAL1409 in contig CT573213_GR.
KEGGfal:FRAAL1409.
PATRIC21912629. VBIFraAln347_1278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4229.
HOGENOMHBG294242.
OMATTDLNFI.
PhylomeDBQ0RQV6.
ProtClustDBCLSK866737.

Enzyme and pathway databases

BioCycFALN326424:FRAAL1409-MONOMER.

Family and domain databases

HAMAPMF_01681. Salvage_MtnC.
[Tree]
InterProIPR005834. Dehalogen-like_hydro.
IPR023943. Enolase-phosphatase_E1.
IPR010041. Enolase_ppase.
IPR023214. HAD-like_dom.
IPR006402. HAD-SF_hydro_IA_v3.
IPR005833. Haloacid_DH/epoxide_hydro.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KOK09880.
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00413. HADHALOGNASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01691. Enolase-ppase. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTNC_FRAAA
AccessionPrimary (citable) accession number: Q0RQV6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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