Q0RNS4 (Q0RNS4_FRAAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL CAJ60812.1
Ordered Locus Names:	FRAAL2163

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP] EMBL CAJ60812.1

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL CAJ60812.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0RNS4 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: F00CD90036744621	FASTA	285	30,792
	10 20 30 40 50 60 MGEFLASGRP SFSFEFFPPR TPEGERHLWT ALRRIEALRP SFVSVTYGAG GSTREGTIRV 70 80 90 100 110 120 TERIATDTTL TPIAHLTAVN HSVAELRQVI GNYAGAGVRN VIALRGDPPG DPQGTWTAHP 130 140 150 160 170 180 QGLEHADELV RLVKSVGDFC VGVAAFPDRH PRSPDFDTDA RYLVGKFDAG ADYAITQFFF 190 200 210 220 230 240 GADDYFRLVE RVRALGCDKP IIPGIMPVTN VAQIVRMAQL SGAAFPPALA ARLQAVADDP 250 260 270 280 AAVRAVGLEV ATELSRRLLD GGAPGLHFIT LNRSSATREI FEAVR

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573213 Genomic DNA. Translation: CAJ60812.1.
RefSeq	YP_712391.1. NC_008278.1.
3D structure databases
ProteinModelPortal	Q0RNS4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0RNS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4232585.
GenomeReviews	Gene locus FRAAL2163 in contig CT573213_GR.
KEGG	fal:FRAAL2163.
PATRIC	21914038. VBIFraAln347_1976.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q0RNS4.
ProtClustDB	CLSK2775829.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0RNS4_FRAAA

Accession

Primary (citable) accession number: Q0RNS4

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)