Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFALN326424:G1GJE-1953-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:FRAAL2193
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei120 – 140HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei185 – 205HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei276 – 296HelicalUniRule annotationAdd BLAST21
Transmembranei330 – 350HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029741 – 355Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST355

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL2193

Structurei

3D structure databases

SMRiQ0RNP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0RNP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGVLIAAMV ALVVSLLGTP WVIRFFRRQG YGQEIREDGP SSHLTKRGTP
60 70 80 90 100
TMGGTVIIVA TLVGYFLAHL VTGIGFTASG LLVLLVMTGL GIVGFLDDYI
110 120 130 140 150
KIRKQRSLGL TARMKFTGQA AVALAFGLLA VRFKNHAGLL PGSTYISIVR
160 170 180 190 200
DTSLTVGIIG FPLLAWIIIA ATSNAVNLTD GLDGLAAGTS AMVFGAYVVI
210 220 230 240 250
SFWQFGNLCE PGDSPAGCYA VRDPLDVALV AAAAMGACFG FLWWNASPAK
260 270 280 290 300
IFMGDTGSLA LGGAFASIAI VSRTELLLVV LGGLFVIETL SVMIQVAFFK
310 320 330 340 350
ATKKRVFNMA PIHHHFELAE WPETTVIIRF WIVSGLAVAF GLGLFYAEFL

SHGNG
Length:355
Mass (Da):37,724
Last modified:September 5, 2006 - v1
Checksum:i9C13722EC2E1C611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA Translation: CAJ60842.1
RefSeqiWP_011603358.1, NC_008278.1

Genome annotation databases

KEGGifal:FRAAL2193

Similar proteinsi

Entry informationi

Entry nameiMRAY_FRAAA
AccessioniPrimary (citable) accession number: Q0RNP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health