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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha

Gene

accD

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43ZincBy similarity1
Metal bindingi46ZincBy similarity1
Metal bindingi62ZincBy similarity1
Metal bindingi65ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 65C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (EC:6.4.1.2)
Short name:
ACCase subunits beta/alpha
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Gene namesi
Name:accD
Synonyms:accA, accDA
Ordered Locus Names:FRAAL3196
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591141 – 609Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alphaAdd BLAST609

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.By similarity

Protein-protein interaction databases

STRINGi326424.FRAAL3196.

Structurei

3D structure databases

ProteinModelPortaliQ0RKW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 308CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST270
Domaini314 – 559CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 271Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaBy similarityAdd BLAST271
Regioni39 – 559CarboxyltransferasePROSITE-ProRule annotationAdd BLAST521
Regioni272 – 582Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaBy similarityAdd BLAST311

Sequence similaritiesi

In the N-terminal section; belongs to the AccD/PCCB family.Curated
In the C-terminal section; belongs to the AccA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 65C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105D8K. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
HOGENOMiHOG000244564.
KOiK01962.
K01963.
OMAiRVLMCAN.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00513. accA. 1 hit.
TIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RKW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEATAIEA TAIEATGIEA TGITATAIEP TPRRSPGSSW LLCGGCGTML
60 70 80 90 100
YERRFAREGR VCADCSWHAP MTIQQRLDLL LDADSARPVD VPAIDGDPLE
110 120 130 140 150
FTDTRPYRDR LRDARASTGL DEAAACVRGT IDGNPVVVVV MDFRFLGGSL
160 170 180 190 200
GATVGEVFTR GAELALRERT PLLTVTASGG ARMQEGAIAL MQMAKTSQAL
210 220 230 240 250
GQLDEAGILT VSLITDPTFG GVAASFATLA DVIIAEPGAR LGFAGRRVIE
260 270 280 290 300
QTIRQTLPED FQTAEFLLTH GVVDLISPRR ELRANLARLL SVSSRRADGI
310 320 330 340 350
PRQAGRPDRA VVTDPEQLAR RDAWESVRAA RRLGRPTTLD YAAMILEDFT
360 370 380 390 400
ELRGDRMSAD CPALVAGLGR LDGVPVAVLG TQKGHTADEL RYRNFGMPTP
410 420 430 440 450
AGYRKSARVM RLAAKLGLPV ITLIDTAGAY PGVEAEEQAQ AVAIAENLRL
460 470 480 490 500
MAGLPVPVVA VVTGEGGSGG ALALAFADRV LMCANAVYSV ISAEGCAAIL
510 520 530 540 550
WKNPAAAPTA AAALRVDARE LLRLGVVDGV IPEPDGGADA DPAGTAARLR
560 570 580 590 600
EALRGALADL LPLDQMNLVT RRRARFRQFG VATPAPATAP AASDDAHESQ

TDRSVEATR
Length:609
Mass (Da):64,294
Last modified:September 5, 2006 - v1
Checksum:i2CF7B04E826734EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ61840.1.
RefSeqiWP_011604345.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL3196.

Similar proteinsi

Entry informationi

Entry nameiACCDA_FRAAA
AccessioniPrimary (citable) accession number: Q0RKW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 5, 2006
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families