ID   UPPP1_FRAAA             Reviewed;         278 AA.
AC   Q0RKT0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Undecaprenyl-diphosphatase 1;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 1;
DE   AltName: Full=Bacitracin resistance protein 1;
GN   Name=uppP1; OrderedLocusNames=FRAAL3231;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CT573213; CAJ61875.1; -; Genomic_DNA.
DR   RefSeq; YP_713442.1; -.
DR   GeneID; 4231404; -.
DR   GenomeReviews; CT573213_GR; FRAAL3231.
DR   KEGG; fal:FRAAL3231; -.
DR   OMA; Q0RKT0; AYASIAW.
DR   BioCyc; FALN326424:FRAAL3231-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; -; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
DR   TIGRFAMs; TIGR00753; undec_PP_bacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    278       Undecaprenyl-diphosphatase 1.
FT                                /FTId=PRO_0000290709.
FT   TRANSMEM     46     66       Potential.
FT   TRANSMEM     91    111       Potential.
FT   TRANSMEM    119    139       Potential.
FT   TRANSMEM    153    173       Potential.
FT   TRANSMEM    191    211       Potential.
FT   TRANSMEM    225    245       Potential.
FT   TRANSMEM    256    276       Potential.
SQ   SEQUENCE   278 AA;  29238 MW;  912E36430A50526F CRC64;
     MSAISVGQAI ILGVVEGLTE FLPISSTGHL KIAEGLMDIQ VDDKAVVGFT AVIQVGAIAA
     VLVYFFADIR RFVTAWGRGL ANPAARTNHD YTFTWWVIYA TIPVVLVGLA AKPLIDGPLA
     SLWVVAASLL AGSALMWFAD QYGRHKRGED DLSLPDAMIV GTSQILALLF PGFSRSGATI
     STGLIRDLDR VAATRLSFFL SIPALTGAGL YELKDAVGGG VSAAPLAVGT VVSFFVAYAS
     IAWLLKFVAR HNFNAFIIYR VAVAVLLAGL LAGGAINA
//