Reviewed, UniProtKB/Swiss-Prot Q0RKT0 (UPPP1_FRAAA)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	FRAAL3231

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP]

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000290709
Regions
	Transmembrane	46 – 66	21	Potential
	Transmembrane	91 – 111	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	153 – 173	21	Potential
	Transmembrane	191 – 211	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	256 – 276	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0RKT0-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 912E36430A50526F	FASTA	278	29,238
	10 20 30 40 50 60 MSAISVGQAI ILGVVEGLTE FLPISSTGHL KIAEGLMDIQ VDDKAVVGFT AVIQVGAIAA 70 80 90 100 110 120 VLVYFFADIR RFVTAWGRGL ANPAARTNHD YTFTWWVIYA TIPVVLVGLA AKPLIDGPLA 130 140 150 160 170 180 SLWVVAASLL AGSALMWFAD QYGRHKRGED DLSLPDAMIV GTSQILALLF PGFSRSGATI 190 200 210 220 230 240 STGLIRDLDR VAATRLSFFL SIPALTGAGL YELKDAVGGG VSAAPLAVGT VVSFFVAYAS 250 260 270 IAWLLKFVAR HNFNAFIIYR VAVAVLLAGL LAGGAINA

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CT573213 Genomic DNA. Translation: CAJ61875.1.
RefSeq	YP_713442.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4231404.
GenomeReviews	Gene locus FRAAL3231 in contig CT573213_GR.
KEGG	fal:FRAAL3231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q0RKT0. AYASIAW.
Enzyme and pathway databases
BioCyc	FALN326424:FRAAL3231-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_FRAAA

Accession

Primary (citable) accession number: Q0RKT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)