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Q0RKT0

- UPPP1_FRAAA

UniProt

Q0RKT0 - UPPP1_FRAAA

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Protein

Undecaprenyl-diphosphatase 1

Gene
uppP1, FRAAL3231
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFALN326424:GJ82-3186-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene namesi
Name:uppP1
Ordered Locus Names:FRAAL3231
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei91 – 11121Helical; Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST
Transmembranei153 – 17321Helical; Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Undecaprenyl-diphosphatase 1UniRule annotationPRO_0000290709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL3231.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAISEITW.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RKT0-1 [UniParc]FASTAAdd to Basket

« Hide

MSAISVGQAI ILGVVEGLTE FLPISSTGHL KIAEGLMDIQ VDDKAVVGFT    50
AVIQVGAIAA VLVYFFADIR RFVTAWGRGL ANPAARTNHD YTFTWWVIYA 100
TIPVVLVGLA AKPLIDGPLA SLWVVAASLL AGSALMWFAD QYGRHKRGED 150
DLSLPDAMIV GTSQILALLF PGFSRSGATI STGLIRDLDR VAATRLSFFL 200
SIPALTGAGL YELKDAVGGG VSAAPLAVGT VVSFFVAYAS IAWLLKFVAR 250
HNFNAFIIYR VAVAVLLAGL LAGGAINA 278
Length:278
Mass (Da):29,238
Last modified:September 5, 2006 - v1
Checksum:i912E36430A50526F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ61875.1.
RefSeqiWP_011604380.1. NC_008278.1.
YP_713442.1. NC_008278.1.

Genome annotation databases

GeneIDi4231404.
KEGGifal:FRAAL3231.
PATRICi21916000. VBIFraAln347_2956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ61875.1 .
RefSeqi WP_011604380.1. NC_008278.1.
YP_713442.1. NC_008278.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL3231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4231404.
KEGGi fal:FRAAL3231.
PATRICi 21916000. VBIFraAln347_2956.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi AISEITW.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci FALN326424:GJ82-3186-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiUPPP1_FRAAA
AccessioniPrimary (citable) accession number: Q0RKT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi