ID   UPPP2_FRAAA             Reviewed;         343 AA.
AC   Q0RJJ1;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Undecaprenyl-diphosphatase 2;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 2;
DE   AltName: Full=Bacitracin resistance protein 2;
GN   Name=uppP2; OrderedLocusNames=FRAAL3678;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CT573213; CAJ62321.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_713882.2; -.
DR   GeneID; 4233855; -.
DR   GenomeReviews; CT573213_GR; FRAAL3678.
DR   KEGG; fal:FRAAL3678; -.
DR   BioCyc; FALN326424:FRAAL3678-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; atypical; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    343       Undecaprenyl-diphosphatase 2.
FT                                /FTId=PRO_0000290710.
FT   TRANSMEM     21     41       Potential.
FT   TRANSMEM     57     77       Potential.
FT   TRANSMEM    104    124       Potential.
FT   TRANSMEM    129    149       Potential.
FT   TRANSMEM    225    245       Potential.
FT   TRANSMEM    265    285       Potential.
FT   TRANSMEM    294    314       Potential.
FT   TRANSMEM    322    342       Potential.
SQ   SEQUENCE   343 AA;  36281 MW;  6053DCD863F84320 CRC64;
     MHELTYLQAG VIGLLQGITE LFPVSSLGHS VLIPALIGGS WQHLVTENAS GNSEGSPYLT
     FVVGLHVATA VALLVFFRSD WARVIRAFLT TLRTRRIETS AQRLAWLIVA ATVPVGIIGL
     ALEHTFRTLF AKPLAAALFL TANGMILLAG ERLRRRSEQR AGTHQASARA EPATIPLTVP
     APATVPTQTT SAPGGRATAR HTTAPRGGLV VSEHRSLDTL AYREAGVIGL FQTLALLAGI
     SRSGITMVAG LLRGLDHEDA ARFSFLLATP VILAAGLLKL PALAGPAGDG IRGQVILGAL
     IAGIAAYLSI RFLVRYFETR TLTPFAIYCL LTGALCTVRF AIA
//