Reviewed, UniProtKB/Swiss-Prot Q0RJJ1 (UPPP2_FRAAA)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	FRAAL3678

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP]

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000290710
Regions
	Transmembrane	21 – 41	21	Potential
	Transmembrane	57 – 77	21	Potential
	Transmembrane	104 – 124	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	265 – 285	21	Potential
	Transmembrane	294 – 314	21	Potential
	Transmembrane	322 – 342	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0RJJ1-1 [UniParc]. Last modified June 12, 2007. Version 2. Checksum: 6053DCD863F84320	FASTA	343	36,281
	10 20 30 40 50 60 MHELTYLQAG VIGLLQGITE LFPVSSLGHS VLIPALIGGS WQHLVTENAS GNSEGSPYLT 70 80 90 100 110 120 FVVGLHVATA VALLVFFRSD WARVIRAFLT TLRTRRIETS AQRLAWLIVA ATVPVGIIGL 130 140 150 160 170 180 ALEHTFRTLF AKPLAAALFL TANGMILLAG ERLRRRSEQR AGTHQASARA EPATIPLTVP 190 200 210 220 230 240 APATVPTQTT SAPGGRATAR HTTAPRGGLV VSEHRSLDTL AYREAGVIGL FQTLALLAGI 250 260 270 280 290 300 SRSGITMVAG LLRGLDHEDA ARFSFLLATP VILAAGLLKL PALAGPAGDG IRGQVILGAL 310 320 330 340 IAGIAAYLSI RFLVRYFETR TLTPFAIYCL LTGALCTVRF AIA

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573213 Genomic DNA. Translation: CAJ62321.1. Different initiation.
RefSeq	YP_713882.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0RJJ1.
Genome annotation databases
GeneID	4233855.
GenomeReviews	Gene locus FRAAL3678 in contig CT573213_GR.
KEGG	fal:FRAAL3678.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
Enzyme and pathway databases
BioCyc	FALN326424:FRAAL3678-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. Divergent sequence. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP2_FRAAA

Accession

Primary (citable) accession number: Q0RJJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	January 19, 2010
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)