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Q0RJJ1 (UPPP2_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:FRAAL3678
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP]
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence CAJ62321.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000290710

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane294 – 31421Helical; Potential
Transmembrane322 – 34221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0RJJ1 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: 6053DCD863F84320

FASTA34336,281
        10         20         30         40         50         60 
MHELTYLQAG VIGLLQGITE LFPVSSLGHS VLIPALIGGS WQHLVTENAS GNSEGSPYLT 

        70         80         90        100        110        120 
FVVGLHVATA VALLVFFRSD WARVIRAFLT TLRTRRIETS AQRLAWLIVA ATVPVGIIGL 

       130        140        150        160        170        180 
ALEHTFRTLF AKPLAAALFL TANGMILLAG ERLRRRSEQR AGTHQASARA EPATIPLTVP 

       190        200        210        220        230        240 
APATVPTQTT SAPGGRATAR HTTAPRGGLV VSEHRSLDTL AYREAGVIGL FQTLALLAGI 

       250        260        270        280        290        300 
SRSGITMVAG LLRGLDHEDA ARFSFLLATP VILAAGLLKL PALAGPAGDG IRGQVILGAL 

       310        320        330        340 
IAGIAAYLSI RFLVRYFETR TLTPFAIYCL LTGALCTVRF AIA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT573213 Genomic DNA. Translation: CAJ62321.1. Different initiation.
RefSeqYP_713882.2. NC_008278.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326424.FRAAL3678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4233855.
KEGGfal:FRAAL3678.
PATRIC21916832. VBIFraAln347_3372.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycFALN326424:GJ82-3626-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP2_FRAAA
AccessionPrimary (citable) accession number: Q0RJJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families