ID   UPPP3_FRAAA             Reviewed;         297 AA.
AC   Q0RHR9;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Undecaprenyl-diphosphatase 3;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 3;
DE   AltName: Full=Bacitracin resistance protein 3;
GN   Name=uppP3; OrderedLocusNames=FRAAL4312;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CT573213; CAJ62954.1; -; Genomic_DNA.
DR   RefSeq; YP_714505.1; -.
DR   GeneID; 4235234; -.
DR   GenomeReviews; CT573213_GR; FRAAL4312.
DR   KEGG; fal:FRAAL4312; -.
DR   OMA; Q0RHR9; FGLLFKD.
DR   BioCyc; FALN326424:FRAAL4312-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; -; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
DR   TIGRFAMs; TIGR00753; undec_PP_bacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    297       Undecaprenyl-diphosphatase 3.
FT                                /FTId=PRO_0000290711.
FT   TRANSMEM     39     59       Potential.
FT   TRANSMEM     89    109       Potential.
FT   TRANSMEM    118    138       Potential.
FT   TRANSMEM    203    223       Potential.
FT   TRANSMEM    237    257       Potential.
FT   TRANSMEM    268    288       Potential.
SQ   SEQUENCE   297 AA;  31549 MW;  D2880E9FB09A3656 CRC64;
     MNYFEGTVLG LVQGLTEFLP VSSSAHLRIT AALAGWDDPG AAFTAVTQIG TETAVLIYFR
     RDIARIVRAW ALSWTRREMR KDTDARVGWL VLLGTIPIGL LGVTLQDAIE GPFRDLRLIA
     TTLIVLGLIL GGADWYASKG RPRGRHSLPR PRKTLRDLSV RDGLLYGLAQ SAALIPGVSR
     SGATISGGLL LGYTREAAAR YSFLLAMPAV LASGVFELKS IGGDREGGDG EEVSWGPTIV
     ATVVAFATGY AAIAWFLRYI STRSFAPFVL YRVALGLLLL ALLAGGAISA DAGAAAD
//