Reviewed, UniProtKB/Swiss-Prot Q0RHR9 (UPPP3_FRAAA)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 3
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 3
    Bacitracin resistance protein 3

Gene names

Name:	uppP3
Ordered Locus Names:	FRAAL4312

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP]

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Undecaprenyl-diphosphatase 3 HAMAP MF_01006		PRO_0000290711
Regions
	Transmembrane	39 – 59	21	Potential
	Transmembrane	89 – 109	21	Potential
	Transmembrane	118 – 138	21	Potential
	Transmembrane	203 – 223	21	Potential
	Transmembrane	237 – 257	21	Potential
	Transmembrane	268 – 288	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0RHR9-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: D2880E9FB09A3656	FASTA	297	31,549
	10 20 30 40 50 60 MNYFEGTVLG LVQGLTEFLP VSSSAHLRIT AALAGWDDPG AAFTAVTQIG TETAVLIYFR 70 80 90 100 110 120 RDIARIVRAW ALSWTRREMR KDTDARVGWL VLLGTIPIGL LGVTLQDAIE GPFRDLRLIA 130 140 150 160 170 180 TTLIVLGLIL GGADWYASKG RPRGRHSLPR PRKTLRDLSV RDGLLYGLAQ SAALIPGVSR 190 200 210 220 230 240 SGATISGGLL LGYTREAAAR YSFLLAMPAV LASGVFELKS IGGDREGGDG EEVSWGPTIV 250 260 270 280 290 ATVVAFATGY AAIAWFLRYI STRSFAPFVL YRVALGLLLL ALLAGGAISA DAGAAAD

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573213 Genomic DNA. Translation: CAJ62954.1.
RefSeq	YP_714505.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0RHR9.
Genome annotation databases
GeneID	4235234.
GenomeReviews	Gene locus FRAAL4312 in contig CT573213_GR.
KEGG	fal:FRAAL4312.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	ITIGWEF.
PhylomeDB	Q0RHR9.
Enzyme and pathway databases
BioCyc	FALN326424:FRAAL4312-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP3_FRAAA

Accession

Primary (citable) accession number: Q0RHR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	September 5, 2006
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)