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Q0RHR9

- UPPP3_FRAAA

UniProt

Q0RHR9 - UPPP3_FRAAA

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Protein

Undecaprenyl-diphosphatase 3

Gene
uppP3, FRAAL4312
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFALN326424:GJ82-4250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 3 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 3
Undecaprenyl pyrophosphate phosphatase 3
Gene namesi
Name:uppP3
Ordered Locus Names:FRAAL4312
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Transmembranei203 – 22321Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Transmembranei268 – 28821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Undecaprenyl-diphosphatase 3UniRule annotationPRO_0000290711Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL4312.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RHR9-1 [UniParc]FASTAAdd to Basket

« Hide

MNYFEGTVLG LVQGLTEFLP VSSSAHLRIT AALAGWDDPG AAFTAVTQIG    50
TETAVLIYFR RDIARIVRAW ALSWTRREMR KDTDARVGWL VLLGTIPIGL 100
LGVTLQDAIE GPFRDLRLIA TTLIVLGLIL GGADWYASKG RPRGRHSLPR 150
PRKTLRDLSV RDGLLYGLAQ SAALIPGVSR SGATISGGLL LGYTREAAAR 200
YSFLLAMPAV LASGVFELKS IGGDREGGDG EEVSWGPTIV ATVVAFATGY 250
AAIAWFLRYI STRSFAPFVL YRVALGLLLL ALLAGGAISA DAGAAAD 297
Length:297
Mass (Da):31,549
Last modified:September 5, 2006 - v1
Checksum:iD2880E9FB09A3656
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ62954.1.
RefSeqiWP_011605438.1. NC_008278.1.
YP_714505.1. NC_008278.1.

Genome annotation databases

GeneIDi4235234.
KEGGifal:FRAAL4312.
PATRICi21918016. VBIFraAln347_3964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ62954.1 .
RefSeqi WP_011605438.1. NC_008278.1.
YP_714505.1. NC_008278.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL4312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4235234.
KEGGi fal:FRAAL4312.
PATRICi 21918016. VBIFraAln347_3964.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci FALN326424:GJ82-4250-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiUPPP3_FRAAA
AccessioniPrimary (citable) accession number: Q0RHR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi