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Protein

Alkyl hydroperoxide reductase AhpD

Gene

ahpD

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Proton donorUniRule annotation
Active sitei134 – 1341Cysteine sulfenic acid (-SOH) intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciFALN326424:GJ82-4428-MONOMER.

Protein family/group databases

PeroxiBasei4631. FalAhpD.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDUniRule annotation (EC:1.11.1.15UniRule annotation)
Alternative name(s):
Alkylhydroperoxidase AhpDUniRule annotation
Gene namesi
Name:ahpDUniRule annotation
Ordered Locus Names:FRAAL4493
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Alkyl hydroperoxide reductase AhpDPRO_0000359488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi131 ↔ 134By similarity
Disulfide bondi134 – 134Interchain (with AhpC); in linked formUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL4493.

Structurei

3D structure databases

ProteinModelPortaliQ0RH96.
SMRiQ0RH96. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AhpD family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD. 1 hit.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RH96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVARLRELL PDYARDLRLN LGSVTSQSNL SAQQLWGTVL AAAIASRGRT
60 70 80 90 100
VLVELEPEAL DHLSAEAATA ARTAAALMAM NNVYYRSLHL LEDEEYSRLR
110 120 130 140 150
AGLRMNALAN PGVDKVDVEL WSLAVSAVNG CGRCLTAHEH ELRGRGVARE
160 170 180
VIQDAIRVAS VVHAVAVTVE ALETSSGTNR VAAAD
Length:185
Mass (Da):19,828
Last modified:September 5, 2006 - v1
Checksum:iC0F1CD64AD13A48D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ63135.1.
RefSeqiWP_011605614.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL4493.
PATRICi21918358. VBIFraAln347_4135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ63135.1.
RefSeqiWP_011605614.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RH96.
SMRiQ0RH96. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL4493.

Protein family/group databases

PeroxiBasei4631. FalAhpD.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL4493.
PATRICi21918358. VBIFraAln347_4135.

Phylogenomic databases

eggNOGiCOG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.

Enzyme and pathway databases

BioCyciFALN326424:GJ82-4428-MONOMER.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD. 1 hit.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAHPD_FRAAA
AccessioniPrimary (citable) accession number: Q0RH96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.