ID   Q0RGS3_FRAAA            Unreviewed;       730 AA.
AC   Q0RGS3;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Putative eukaryotic-type serine/threonine protein kinase {ECO:0000313|EMBL:CAJ63313.1};
DE            EC=2.7.1.- {ECO:0000313|EMBL:CAJ63313.1};
GN   OrderedLocusNames=FRAAL4671 {ECO:0000313|EMBL:CAJ63313.1};
OS   Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ63313.1, ECO:0000313|Proteomes:UP000000657};
RN   [1] {ECO:0000313|EMBL:CAJ63313.1, ECO:0000313|Proteomes:UP000000657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC       protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR   EMBL; CT573213; CAJ63313.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0RGS3; -.
DR   STRING; 326424.FRAAL4671; -.
DR   KEGG; fal:FRAAL4671; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG3386; Bacteria.
DR   HOGENOM; CLU_383001_0_0_11; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43671:SF13; LD04361P; 1.
DR   PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR   Pfam; PF01436; NHL; 3.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51125; NHL; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:CAJ63313.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000000657};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAJ63313.1};
KW   Transferase {ECO:0000313|EMBL:CAJ63313.1}.
FT   DOMAIN          40..294
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REPEAT          395..427
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          679..722
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REGION          367..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         69
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   730 AA;  74737 MW;  226C1865CAFF1ABA CRC64;
     MAAWLGLLAC DTDFRSGAAG PLPPDMIIDR RRVQKALPGY ALGAELGSGA FGLVLAGKHR
     RLGRPVAIKV MQAEGPEGRS LDFAAEARVL AGFDHPHVVK AYDYVEAEGL CLVVMELLAG
     GTLSRRRAGM TPQAGCAVGL AVAAALEHAH SFGVLHRDIK GDNILFTADG IAKVTDFGIA
     KLLEGSGATA SSRSGTPMYM APEQIDGGRL GPATDLYALG VVMYQLLTGA PPFDPRQSVS
     RLWRQHLTDP PPPMIDVPAP LAAVVLRALA KKSADRQPDA RTFALELAAA AATVYGPGWA
     GIPLRLDADI RSTANLMPAP IRPPSGMASR HRSSPAVGRT RFRPRWVVAV ALAALAATST
     LVALRSNNGS SPTSSGTFNT PTPTPAPGPA AVAVGPLSRP AGVAVGGDGS VYIADIEEHR
     VWKVDRAGRM STLAGTGTAG FSGDGGPANR AQVNWVAALA VGADSSVYMV DSNLDLDESR
     IRKIDGAGRI STIAGNGRAV DLGESGSSGD GGPALDSPLS GVGALAVGAD GVVYLADEAS
     NRIRRVDRAG LISTFAGAGT SPSPSRFFGD GGPATRAQLD CGNACGVAVG ADGSVYIADE
     GNNRIRKVDQ AGRISTIAGN GSLGFAGDGG LAIQAQMMYP LQVAVGPDSS VYILDDANDV
     RKVDPSGRIT LFAGNGTGGF SGDGGPATRA QMNQPSAIAV GSDGSVYIAD EGNKRIRKID
     PAGRINTIAR
//