Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q0RFQ0 (Q0RFQ0_FRAAA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL CAJ63691.1
Ordered Locus Names:FRAAL5051
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP] EMBL CAJ63691.1
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
Q0RFQ0 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: E7C6B13F26D97254

FASTA926102,594
        10         20         30         40         50         60 
MAQDTTRKFS VITDGLPSQL PDIDPSETNE WLESLDAVIE ESGRGRARFL MLKLLERARE 

        70         80         90        100        110        120 
KAVGVPGLTS TDYINTIPPE REPWFPGDEH VERRIRAYIR WNAAIMVSRA NRPEFNVGGH 

       130        140        150        160        170        180 
IATYASSASL YEVGFNHFFR GKDHLSSSPG SDSGDQIFIQ GHASPGIYAR AFLEGRLTES 

       190        200        210        220        230        240 
QLDAFRRESE SGGLSSYPHP RLMPDFWEFP TVSMGLGPID AIYQARFNRY LLNRQIKDTS 

       250        260        270        280        290        300 
NSRVWAFLGD GEMDEPESIG ALGVAAREEL DNLIFVVNCN LQRLDGPVRG NGKIMQELES 

       310        320        330        340        350        360 
LFRGAGWNVI KVVWGRDWDP LLAKDTDGTL VHRMNTTPDG QFQTYTTSSG EYIREHFFGA 

       370        380        390        400        410        420 
DARLRRMVAD LADDDLRKLS RGGHDYRKLY AAYKAATEHT GQPTVILAHT IKGWTLGKDF 

       430        440        450        460        470        480 
EARNATHQMK KLTKAELKEF RDRLYLEIPD SALAGDLPPY YHPGPDSEEI QYMRERRASL 

       490        500        510        520        530        540 
GGSMPRRVVR AKPLPQPPAK IFDELRKGSG KQPVATTMAF VRLLKDLMKT KEMGARFVPV 

       550        560        570        580        590        600 
IPDEARTFGM DAMFPTAKIY SPHGQRYEAV DRELLLSYQE SESGQMLHEG ISEAGSMGSV 

       610        620        630        640        650        660 
IAAATSYSTH AQYMIPVYVF YSMFGFQRTG DQMWALGDQL GRGFLLGATA GRTTLNGEGL 

       670        680        690        700        710        720 
QHQDGHSLLL ASTNPACVAY DPAFAFEVSH IVRDALDRMY GERDENVFYY LTVYNEPVPQ 

       730        740        750        760        770        780 
PAEPAGLDPA QIIAGMYRFR PAEELVGGLP SGGAEGGSGP RAQLLASGTS IHWALTAQEI 

       790        800        810        820        830        840 
LAADFGVAAD VWSVTSWNEL RREALDCERA NLLNPEADDA VPYVTRILDG APGPVVAVSD 

       850        860        870        880        890        900 
WMRAVPDQIS RWVPQAFTSL GTDGYGRSDT RLALRRHFKV DAESVVVAAL ESLVRAGEVK 

       910        920 
ASLVEDAIRR FGLRDDDDAV GGTDAG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573213 Genomic DNA. Translation: CAJ63691.1.
RefSeqYP_715231.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0RFQ0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0RFQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4235338.
GenomeReviewsGene locus FRAAL5051 in contig CT573213_GR.
KEGGfal:FRAAL5051.
PATRIC21919352. VBIFraAln347_4630.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
HOGENOMHBG289271.
OMAFRQEKSH.
PhylomeDBQ0RFQ0.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0RFQ0_FRAAA
AccessionPrimary (citable) accession number: Q0RFQ0
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info