Q0RFF6 (GCST_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	FRAAL5148

Organism

Frankia alni (strain ACN14a) [Complete proteome] [HAMAP]

Taxonomic identifier

326424 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000047665

Sequences

	Sequence		Length	Mass (Da)
	Q0RFF6 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: DD60D9675E66BA1F	FASTA	365	38,064
	10 20 30 40 50 60 MADLRRSPLY GRHVDLGAKM AGFGGWEMPI EYAGRGVLAE HQAVRGAVGI FDVSHLGKAE 70 80 90 100 110 120 VTGAGAAEFV NACLSNDLGR IAPGQAQYTL CCNDEGGVVD DLIAYLFSGE RVLLVPNAAN 130 140 150 160 170 180 NAEVVARLAA AAPAGVSVTD RHTGFGVLAV QGPAAPTLVA ALGLPTDGAY MSFVEAAWKG 190 200 210 220 230 240 RPVIVCRSGY TGERGYELLP RWDDTPALWD ALFAAGEGLG ASPVGLGARD TLRTEMGYPL 250 260 270 280 290 300 HGQDLSPTIT PVQARSGWAV GWGKERFWGR EALLAERAAG PARLLWGLAS TGRAIPRPHM 310 320 330 340 350 360 PVTAADGAPV GEVTSGTFSP TLRQGIGLAL LDRGVAEGDT VNVDVRGRPG PMTVVRPPFV PSTPR

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACN14a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573213 Genomic DNA. Translation: CAJ63788.1.
RefSeq	YP_715325.1. NC_008278.1.
3D structure databases
ProteinModelPortal	Q0RFF6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0RFF6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4233028.
GenomeReviews	Gene locus FRAAL5148 in contig CT573213_GR.
KEGG	fal:FRAAL5148.
PATRIC	21919530. VBIFraAln347_4719.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	GYPLHGQ.
PhylomeDB	Q0RFF6.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	FALN326424:FRAAL5148-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_FRAAA

Accession

Primary (citable) accession number: Q0RFF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program