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Protein

Argininosuccinate lyase

Gene

argH

Organism
Frankia alni (strain ACN14a)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciFALN326424:FRAAL_RS22675-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotationImported
Ordered Locus Names:FRAAL5201Imported
OrganismiFrankia alni (strain ACN14a)Imported
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL5201

Structurei

3D structure databases

ProteinModelPortaliQ0RFB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 340Lyase_1InterPro annotationAdd BLAST284
Domaini403 – 469ASL_C2InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q0RFB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTDHSEEA AVPKPPAGGA TDADAPAGGV LAGGASAGAP MRLWGGRFAG
60 70 80 90 100
GPAEALARLS VSVQFDWRLA PYDLLASKSH ARVLHRAGLL DDAELAAMLA
110 120 130 140 150
AIDDLSDAVA QGRFRPTVED EDVHTALERG LLERLGALGG KLRAGRSRND
160 170 180 190 200
QVATDLRLYL REHARQVAAR LTELSQALVT VAEQHVDTPA PGMTHLQHAQ
210 220 230 240 250
PISFGHQLLA HVQAFVRDTD RLRDWDRRAS VSALGAGALA GSSLPLDPRG
260 270 280 290 300
VAAELGFDRA FDNSLDAVSD RDFAAEFLFV AALIGVHLSR LGEEIVLWTT
310 320 330 340 350
REFGWVELDD AFATGSSIMP QKKNPDVAEL ARGKSGRLIG GLTGFLATLK
360 370 380 390 400
GLPLAYDRDL QEDKEPVFDA VDTLLLVLPA LTGTVATMRV RRERLAAAAP
410 420 430 440 450
DGFALATDVA EYLVRRGVPF RQAHEAVGQL VSWCVAHDVD LDGVSDDDLA
460 470 480 490 500
VINPLLTPDV RGVLSVSGAL QARSAPGGTA PDRVREQLAA LRPVLDRDRA

WAVD
Length:504
Mass (Da):53,650
Last modified:September 5, 2006 - v1
Checksum:i98CF37FB7116B700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA Translation: CAJ63834.1
RefSeqiWP_011606295.1, NC_008278.1

Genome annotation databases

KEGGifal:FRAAL5201

Similar proteinsi

Entry informationi

Entry nameiQ0RFB3_FRAAA
AccessioniPrimary (citable) accession number: Q0RFB3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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