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Protein

Argininosuccinate lyase

Gene

argH

Organism
Frankia alni (strain ACN14a)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciFALN326424:GJ82-5119-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotationImported
Ordered Locus Names:FRAAL5201Imported
OrganismiFrankia alni (strain ACN14a)Imported
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL5201.

Structurei

3D structure databases

ProteinModelPortaliQ0RFB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 340283Lyase_1InterPro annotationAdd
BLAST
Domaini403 – 46967ASL_C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiAHHLMAY.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0RFB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTDHSEEA AVPKPPAGGA TDADAPAGGV LAGGASAGAP MRLWGGRFAG
60 70 80 90 100
GPAEALARLS VSVQFDWRLA PYDLLASKSH ARVLHRAGLL DDAELAAMLA
110 120 130 140 150
AIDDLSDAVA QGRFRPTVED EDVHTALERG LLERLGALGG KLRAGRSRND
160 170 180 190 200
QVATDLRLYL REHARQVAAR LTELSQALVT VAEQHVDTPA PGMTHLQHAQ
210 220 230 240 250
PISFGHQLLA HVQAFVRDTD RLRDWDRRAS VSALGAGALA GSSLPLDPRG
260 270 280 290 300
VAAELGFDRA FDNSLDAVSD RDFAAEFLFV AALIGVHLSR LGEEIVLWTT
310 320 330 340 350
REFGWVELDD AFATGSSIMP QKKNPDVAEL ARGKSGRLIG GLTGFLATLK
360 370 380 390 400
GLPLAYDRDL QEDKEPVFDA VDTLLLVLPA LTGTVATMRV RRERLAAAAP
410 420 430 440 450
DGFALATDVA EYLVRRGVPF RQAHEAVGQL VSWCVAHDVD LDGVSDDDLA
460 470 480 490 500
VINPLLTPDV RGVLSVSGAL QARSAPGGTA PDRVREQLAA LRPVLDRDRA

WAVD
Length:504
Mass (Da):53,650
Last modified:September 5, 2006 - v1
Checksum:i98CF37FB7116B700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ63834.1.
RefSeqiWP_011606295.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL5201.
PATRICi21919618. VBIFraAln347_4760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ63834.1.
RefSeqiWP_011606295.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RFB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL5201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL5201.
PATRICi21919618. VBIFraAln347_4760.

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiAHHLMAY.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciFALN326424:GJ82-5119-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0RFB3_FRAAA
AccessioniPrimary (citable) accession number: Q0RFB3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.