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Q0REL2

- PANC2_FRAAA

UniProt

Q0REL2 - PANC2_FRAAA

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Protein
Pantothenate synthetase 2
Gene
panC2, FRAAL5463
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Proton donor By similarity
Binding sitei196 – 1961ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi167 – 1704ATP By similarity
Nucleotide bindingi204 – 2074ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-5376-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 2 (EC:6.3.2.1)
Short name:
PS 2
Alternative name(s):
Pantoate--beta-alanine ligase 2
Pantoate-activating enzyme 2
Gene namesi
Name:panC2
Ordered Locus Names:FRAAL5463
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Pantothenate synthetase 2UniRule annotation
PRO_0000305454Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL5463.

Structurei

3D structure databases

ProteinModelPortaliQ0REL2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPEAICRS.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0REL2-1 [UniParc]FASTAAdd to Basket

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MSGNGGGIGT GLGSLAGSGR TVTTIAEVRA AADAVRAAGG RVGFFGTSGA    50
LHEGHLTVIR RMAAECDLSI MPLFLAPVPG VTSDAVPAYD RDFDADAALA 100
FDAGVNLVFR PAVAEMYPAL PVRTAVVPAD ELAAPWEGAE DPSFLRMAAT 150
ALAKYYNIVG PCRAYTGEKD WVPLTVLRRM VVDLSIRAEI VACPVVRLAD 200
GLCASSRNSR LSAADRAAAP TLYAALTAAV AAVEAGERDA EAIRSLLRRR 250
ISAVAPVDYA EVVDATTLAR VDPLAGELRL LVSADFTGTH LFDNVGLTVR 300
DADADADARV TVPAVGTTAA APATDRRTSG 330
Length:330
Mass (Da):34,091
Last modified:September 5, 2006 - v1
Checksum:i0782103C69ED6697
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64096.1.
RefSeqiYP_715623.1. NC_008278.1.

Genome annotation databases

GeneIDi4234010.
KEGGifal:FRAAL5463.
PATRICi21920108. VBIFraAln347_5003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64096.1 .
RefSeqi YP_715623.1. NC_008278.1.

3D structure databases

ProteinModelPortali Q0REL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL5463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4234010.
KEGGi fal:FRAAL5463.
PATRICi 21920108. VBIFraAln347_5003.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PEAICRS.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci FALN326424:GJ82-5376-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiPANC2_FRAAA
AccessioniPrimary (citable) accession number: Q0REL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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