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Q0REL2

- PANC2_FRAAA

UniProt

Q0REL2 - PANC2_FRAAA

Protein

Pantothenate synthetase 2

Gene

panC2

Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551Proton donorUniRule annotation
    Binding sitei196 – 1961ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi167 – 1704ATPUniRule annotation
    Nucleotide bindingi204 – 2074ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFALN326424:GJ82-5376-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetase 2UniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PS 2UniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligase 2UniRule annotation
    Pantoate-activating enzyme 2UniRule annotation
    Gene namesi
    Name:panC2UniRule annotation
    Ordered Locus Names:FRAAL5463
    OrganismiFrankia alni (strain ACN14a)
    Taxonomic identifieri326424 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000000657: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Pantothenate synthetase 2PRO_0000305454Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi326424.FRAAL5463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0REL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiPEAICRS.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0REL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGNGGGIGT GLGSLAGSGR TVTTIAEVRA AADAVRAAGG RVGFFGTSGA    50
    LHEGHLTVIR RMAAECDLSI MPLFLAPVPG VTSDAVPAYD RDFDADAALA 100
    FDAGVNLVFR PAVAEMYPAL PVRTAVVPAD ELAAPWEGAE DPSFLRMAAT 150
    ALAKYYNIVG PCRAYTGEKD WVPLTVLRRM VVDLSIRAEI VACPVVRLAD 200
    GLCASSRNSR LSAADRAAAP TLYAALTAAV AAVEAGERDA EAIRSLLRRR 250
    ISAVAPVDYA EVVDATTLAR VDPLAGELRL LVSADFTGTH LFDNVGLTVR 300
    DADADADARV TVPAVGTTAA APATDRRTSG 330
    Length:330
    Mass (Da):34,091
    Last modified:September 5, 2006 - v1
    Checksum:i0782103C69ED6697
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573213 Genomic DNA. Translation: CAJ64096.1.
    RefSeqiYP_715623.1. NC_008278.1.

    Genome annotation databases

    GeneIDi4234010.
    KEGGifal:FRAAL5463.
    PATRICi21920108. VBIFraAln347_5003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT573213 Genomic DNA. Translation: CAJ64096.1 .
    RefSeqi YP_715623.1. NC_008278.1.

    3D structure databases

    ProteinModelPortali Q0REL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326424.FRAAL5463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4234010.
    KEGGi fal:FRAAL5463.
    PATRICi 21920108. VBIFraAln347_5003.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi PEAICRS.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci FALN326424:GJ82-5376-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ACN14a.

    Entry informationi

    Entry nameiPANC2_FRAAA
    AccessioniPrimary (citable) accession number: Q0REL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3