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Q0REL2 (PANC2_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate synthetase 2

Short name=PS 2
EC=6.3.2.1
Alternative name(s):
Pantoate--beta-alanine ligase 2
Pantoate-activating enzyme 2
Gene names
Name:panC2
Ordered Locus Names:FRAAL5463
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP]
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Pantothenate synthetase 2 HAMAP-Rule MF_00158
PRO_0000305454

Regions

Nucleotide binding167 – 1704ATP By similarity
Nucleotide binding204 – 2074ATP By similarity

Sites

Active site551Proton donor By similarity
Binding site1961ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0REL2 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 0782103C69ED6697

FASTA33034,091
        10         20         30         40         50         60 
MSGNGGGIGT GLGSLAGSGR TVTTIAEVRA AADAVRAAGG RVGFFGTSGA LHEGHLTVIR 

        70         80         90        100        110        120 
RMAAECDLSI MPLFLAPVPG VTSDAVPAYD RDFDADAALA FDAGVNLVFR PAVAEMYPAL 

       130        140        150        160        170        180 
PVRTAVVPAD ELAAPWEGAE DPSFLRMAAT ALAKYYNIVG PCRAYTGEKD WVPLTVLRRM 

       190        200        210        220        230        240 
VVDLSIRAEI VACPVVRLAD GLCASSRNSR LSAADRAAAP TLYAALTAAV AAVEAGERDA 

       250        260        270        280        290        300 
EAIRSLLRRR ISAVAPVDYA EVVDATTLAR VDPLAGELRL LVSADFTGTH LFDNVGLTVR 

       310        320        330 
DADADADARV TVPAVGTTAA APATDRRTSG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT573213 Genomic DNA. Translation: CAJ64096.1.
RefSeqYP_715623.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0REL2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326424.FRAAL5463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4234010.
KEGGfal:FRAAL5463.
PATRIC21920108. VBIFraAln347_5003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMAPEAICRS.

Enzyme and pathway databases

BioCycFALN326424:GJ82-5376-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePANC2_FRAAA
AccessionPrimary (citable) accession number: Q0REL2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways