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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi510 – 5101MagnesiumUniRule annotation
Metal bindingi516 – 5161MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-5658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:FRAAL5753
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
ProteomesiUP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Polyribonucleotide nucleotidyltransferasePRO_0000329656Add
BLAST

Proteomic databases

PRIDEiQ0RDT1.

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL5753.

Structurei

3D structure databases

ProteinModelPortaliQ0RDT1.
SMRiQ0RDT1. Positions 3-713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini576 – 63560KHUniRule annotationAdd
BLAST
Domaini647 – 71973S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0RDT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSTHAAEA VIATPAGNRT VRFETGRLAR QAAGSAVAYL GDTMVLSATT
60 70 80 90 100
VSKQPKEQLD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS EDAILTCRLI
110 120 130 140 150
DRPLRPSFAK GLRNEIQVVA TVLALDPDTL YDVVAINAAS ASTTLSGLPF
160 170 180 190 200
TGPIGATRVG YVDGEWIAFP THAELARATF DMVVAGRVVE DGSDVAIMMV
210 220 230 240 250
EAEATPGTVE LIAGGAPAPT EEVVAAGLEA AKPAIRELCR AQSELASLAG
260 270 280 290 300
KAATREFPVF IDHHDDVLEA LSAAVGDELS AALRIAGKSE RENELDRVRQ
310 320 330 340 350
LAAEKVAAQF EGREKEIGAA YRALTKKLVR SRIVTEGVRI DGRSTTEIRE
360 370 380 390 400
LSAEVDYIPR VHGSALFERG ETQILGVTTL AMLRMEQTVD TLNPDRTKRY
410 420 430 440 450
MHNYNFPPYS TGETGRVGSP KRREIGHGAL AERALLPVLP SREEFPYAIR
460 470 480 490 500
QVSEALGSNG STSMGSVCAS TLSLLNAGVP LKAPVAGIAM GLVHADDAYV
510 520 530 540 550
TLTDILGAED AYGDMDFKVA GTRDFVTALQ LDTKLDGIPA SVLASALQQA
560 570 580 590 600
RGARLAILDV MAEAIGSPDE MSAHAPRVIS VKIPVDKIGE VIGPKGKMIN
610 620 630 640 650
QIQADSGAEI TVEDDGTIYI GAADGTSAET ARSAINAIAN PQMPEVGERY
660 670 680 690 700
LGTIVKITNF GAFVSLTPGR DGLLHVSKLK TLSGGKRVEK VEDVLTVGQK
710 720
LQVEITEIDA RGKISLSPSA EAADAAAAS
Length:729
Mass (Da):77,223
Last modified:September 5, 2006 - v1
Checksum:i44BCC52A3DCC123E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ64385.1.
RefSeqiWP_011606827.1. NC_008278.1.
YP_715906.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL5753.
PATRICi21920648. VBIFraAln347_5273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ64385.1.
RefSeqiWP_011606827.1. NC_008278.1.
YP_715906.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RDT1.
SMRiQ0RDT1. Positions 3-713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL5753.

Proteomic databases

PRIDEiQ0RDT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL5753.
PATRICi21920648. VBIFraAln347_5273.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Enzyme and pathway databases

BioCyciFALN326424:GJ82-5658-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiPNP_FRAAA
AccessioniPrimary (citable) accession number: Q0RDT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.