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Q0RCQ1 (Q0RCQ1_FRAAA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH EMBL CAJ64773.1
Synonyms:ispH2 HAMAP MF_00191
Ordered Locus Names:FRAAL6150
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP] EMBL CAJ64773.1
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q0RCQ1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: FBF0C7ED4F2C2B1C

FASTA34437,025
        10         20         30         40         50         60 
MSPSGHASPA ALPARPPPRR LPSMGRVLLA KPRGYCAGVD RAVVTVEKAL ELYGSPVYVR 

        70         80         90        100        110        120 
KQIVHNLHVV RTLEAKGAIF VDETDEVPPG ATVVFSAHGV APTVHEEASA RQLRTIDATC 

       130        140        150        160        170        180 
PLVSKVHSEA RRFAREDYDI LLIGHEGHEE VVGTTGQAPD RIHLVDGPED AAKVKVRDPE 

       190        200        210        220        230        240 
HVAFLSQTTL SVDETQTTVK ALRERFPHLQ GPPSDDICYA TQNRQVAVKE ISSAVDLVIV 

       250        260        270        280        290        300 
VGSPNSSNSV RLVEVALDAG APAAYLVDDS TEVDASWLDG VETVGVTSGA SVPEELVTGV 

       310        320        330        340 
MAWLAERGFN DVEEVTSADE HLLFALPPEL RRDIRARERE TAAS

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT573213 Genomic DNA. Translation: CAJ64773.1.
RefSeqYP_716288.1. NC_008278.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0RCQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4230989.
GenomeReviewsGene locus FRAAL6150 in contig CT573213_GR.
KEGGfal:FRAAL6150.
PATRIC21921386. VBIFraAln347_5635.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAAMAPECD.
PhylomeDBQ0RCQ1.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0RCQ1_FRAAA
AccessionPrimary (citable) accession number: Q0RCQ1
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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