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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateUniRule annotation1
Metal bindingi230ManganeseUniRule annotation1
Metal bindingi250Manganese; via tele nitrogenUniRule annotation1
Binding sitei272SubstrateUniRule annotation1
Active sitei274UniRule annotation1
Metal bindingi297ManganeseUniRule annotation1
Binding sitei389GTPUniRule annotation1
Binding sitei420GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi273 – 278GTPUniRule annotation6
Nucleotide bindingi515 – 518GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:G1GJE-5515-MONOMER
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:FRAAL6204
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000602891 – 607Phosphoenolpyruvate carboxykinase [GTP]Add BLAST607

Proteomic databases

PRIDEiQ0RCJ7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL6204

Structurei

3D structure databases

ProteinModelPortaliQ0RCJ7
SMRiQ0RCJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni221 – 223Substrate bindingUniRule annotation3
Regioni387 – 389Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
HOGENOMiHOG000191700
KOiK01596
OMAiCWLALTD

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q0RCJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAAQIPGL EAAPTKHARL VAWVREIAEL TQPERVEWCD GSEAEFDRLT
60 70 80 90 100
SLLIEKGTLV RLNDEKRPNS FYAASDPSDV ARVEDRTYIC SEKAEDAGPT
110 120 130 140 150
NNWMDPAEMR VKLQGLFEGS MRGRTMYVVP FCMGPLGSHI SALGVEITDS
160 170 180 190 200
PYVVISMRTM TRMGAPALEQ LGEDGFFVPA VHSLGAPLES GAADVPWPCN
210 220 230 240 250
TTKYITHFPE TREIWSYGSG YGGNALLGKK CYALRIASVM ARDEGWLAEH
260 270 280 290 300
MLILKLTSPA GKVHYIAAAF PSACGKTNLA MLIPTLPGWK AETVGDDIAW
310 320 330 340 350
MRFGEDGRLY AVNPEAGFFG VAPGTGEQTN PNAIKTLWGN TVFTNVARTD
360 370 380 390 400
DGDVWWEGLT KQAPGHLTDW KGRDWTPEST EPAAHPNARF TVPAGQCPTI
410 420 430 440 450
ASEWQDPKGV PISAILFGGR RATAVPLVTE APDWRRGVFF GSIVASETTA
460 470 480 490 500
AQAGAIGKLR RDPFAMLPFC GYNMADYFAH WLEVGQKADQ AKLPRIYYVN
510 520 530 540 550
WFRKSPEGKF LWPGFGENSR VLAWIVGRLE GHADGVETPL GVLPTRDALP
560 570 580 590 600
TDGLQIDEAD LDALLTVDID VWKQEAELIP EHYQTFGDRL PAALWAEHEA

LVSRLDG
Length:607
Mass (Da):66,582
Last modified:September 5, 2006 - v1
Checksum:i01D266786EDFF796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA Translation: CAJ64827.1
RefSeqiWP_011607254.1, NC_008278.1

Genome annotation databases

KEGGifal:FRAAL6204

Similar proteinsi

Entry informationi

Entry nameiPCKG_FRAAA
AccessioniPrimary (citable) accession number: Q0RCJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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