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Q0RCJ1

- SYL_FRAAA

UniProt

Q0RCJ1 - SYL_FRAAA

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Protein
Leucine--tRNA ligase
Gene
leuS, FRAAL6210
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei841 – 8411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-6107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:FRAAL6210
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10691069Leucine--tRNA ligaseUniRule annotation
PRO_0000334758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL6210.

Structurei

3D structure databases

ProteinModelPortaliQ0RCJ1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 11812"HIGH" regionUniRule annotation
Add
BLAST
Motifi838 – 8425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0RCJ1-1 [UniParc]FASTAAdd to Basket

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MSQGRRTNEL GWHERMSETA EHGTGAANAT ASPSGAVPPS GATATAGTGD     50
EPGFRYDARL AADIERRWQR RWADEGTFNS PNPVGPLAAG FDEVAGREPF 100
YIMDMFPYPS GTGLHVGHPL GYIGTDVFAR YLRMSGRHVL HPFGYDAFGL 150
PAEQYAINTG QHPRTTTDAN IANMRRQLSR LGLGHDTRRE IATTDVGYYR 200
WTQWIFEQIF DAWYDPQAGR ARPIAELIAE FEAGTRSPAA GPAAGTTAVS 250
VDAVRAANPT GLPWAELDRV TRRRVVDAHR LAYISEQLVN WCPGLGTVLA 300
NEEVTAEGRS DIGNYPVFRR PLRQWVLRIT AYAERLVDDL DLVDWSDSIK 350
QMQRNWIGPS DGAGVEFAVV PPSGSAGAAP GQRIEVYTTR PDTLAGATFL 400
VLAPEHPQVD ALVADAWPAG TPGAWRFPAG RGPAVGEAAE VAAEEVAAEE 450
VGAAEVEAAA ADPAWTPRAA VEAYRAFAAR RSDRQRGEEV DRTGVFTGAY 500
VRNPVGGGLL PVFLADYVLV GYGTGAIMAV PAHDSRDFSF ARAFDLPIPA 550
VLAPDEQWYA EHRVTPGAPP SAWPEAFGGE GAYLPGPAGT PVLAGLTKPD 600
AIKTTVRWLE DGGHGRLARS YRLRDWLFSR QRYWGEPFPI VFDDDGLPYA 650
VPDELLPVEL PEMTDFRPTA MAEDDESDPV PPLARVADWA SVTLDLGDGP 700
KRYRRETNTM PQWAGSCWYH LRYLDPTNTE RFVDETVERY WLAKPGAAAG 750
DGGVDLYVGG VEHAVLHLLY ARFWQKVLYD LGHVSSKEPF KRLFNQGYIQ 800
ADAFTDARGM YVPAAEVKQT DDGRFTHHGA PVDRRSGKMG KSLKNSVSPD 850
EMYERFGADT LRVYEMAMGP LDADRPWHTD DIVGSHRFLQ RLWRAVVDEG 900
SGTVAVSDEQ LDAEATRVLH RTIITLAAEY AGLRFNTAVA RLIELTNYVS 950
KRYGQAATPR ALAEPLVLMV APLAPHIAEE LWTRLGHSES VSRAAFPVGD 1000
PALAAESERT IPVQVNGKVR FTLQVPDGAA EPVIRELLTA HPDYARQTEG 1050
RTIKKTIIVP GRIVNIALG 1069
Length:1,069
Mass (Da):116,994
Last modified:September 5, 2006 - v1
Checksum:i392D3E9F711BC099
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64833.1.
RefSeqiWP_011607260.1. NC_008278.1.
YP_716348.1. NC_008278.1.

Genome annotation databases

GeneIDi4237482.
KEGGifal:FRAAL6210.
PATRICi21921492. VBIFraAln347_5688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64833.1 .
RefSeqi WP_011607260.1. NC_008278.1.
YP_716348.1. NC_008278.1.

3D structure databases

ProteinModelPortali Q0RCJ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL6210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4237482.
KEGGi fal:FRAAL6210.
PATRICi 21921492. VBIFraAln347_5688.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FALN326424:GJ82-6107-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiSYL_FRAAA
AccessioniPrimary (citable) accession number: Q0RCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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