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Q0RCJ1

- SYL_FRAAA

UniProt

Q0RCJ1 - SYL_FRAAA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei841 – 8411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-6107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FRAAL6210
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10691069Leucine--tRNA ligasePRO_0000334758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL6210.

Structurei

3D structure databases

ProteinModelPortaliQ0RCJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 11812"HIGH" regionAdd
BLAST
Motifi838 – 8425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0RCJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQGRRTNEL GWHERMSETA EHGTGAANAT ASPSGAVPPS GATATAGTGD
60 70 80 90 100
EPGFRYDARL AADIERRWQR RWADEGTFNS PNPVGPLAAG FDEVAGREPF
110 120 130 140 150
YIMDMFPYPS GTGLHVGHPL GYIGTDVFAR YLRMSGRHVL HPFGYDAFGL
160 170 180 190 200
PAEQYAINTG QHPRTTTDAN IANMRRQLSR LGLGHDTRRE IATTDVGYYR
210 220 230 240 250
WTQWIFEQIF DAWYDPQAGR ARPIAELIAE FEAGTRSPAA GPAAGTTAVS
260 270 280 290 300
VDAVRAANPT GLPWAELDRV TRRRVVDAHR LAYISEQLVN WCPGLGTVLA
310 320 330 340 350
NEEVTAEGRS DIGNYPVFRR PLRQWVLRIT AYAERLVDDL DLVDWSDSIK
360 370 380 390 400
QMQRNWIGPS DGAGVEFAVV PPSGSAGAAP GQRIEVYTTR PDTLAGATFL
410 420 430 440 450
VLAPEHPQVD ALVADAWPAG TPGAWRFPAG RGPAVGEAAE VAAEEVAAEE
460 470 480 490 500
VGAAEVEAAA ADPAWTPRAA VEAYRAFAAR RSDRQRGEEV DRTGVFTGAY
510 520 530 540 550
VRNPVGGGLL PVFLADYVLV GYGTGAIMAV PAHDSRDFSF ARAFDLPIPA
560 570 580 590 600
VLAPDEQWYA EHRVTPGAPP SAWPEAFGGE GAYLPGPAGT PVLAGLTKPD
610 620 630 640 650
AIKTTVRWLE DGGHGRLARS YRLRDWLFSR QRYWGEPFPI VFDDDGLPYA
660 670 680 690 700
VPDELLPVEL PEMTDFRPTA MAEDDESDPV PPLARVADWA SVTLDLGDGP
710 720 730 740 750
KRYRRETNTM PQWAGSCWYH LRYLDPTNTE RFVDETVERY WLAKPGAAAG
760 770 780 790 800
DGGVDLYVGG VEHAVLHLLY ARFWQKVLYD LGHVSSKEPF KRLFNQGYIQ
810 820 830 840 850
ADAFTDARGM YVPAAEVKQT DDGRFTHHGA PVDRRSGKMG KSLKNSVSPD
860 870 880 890 900
EMYERFGADT LRVYEMAMGP LDADRPWHTD DIVGSHRFLQ RLWRAVVDEG
910 920 930 940 950
SGTVAVSDEQ LDAEATRVLH RTIITLAAEY AGLRFNTAVA RLIELTNYVS
960 970 980 990 1000
KRYGQAATPR ALAEPLVLMV APLAPHIAEE LWTRLGHSES VSRAAFPVGD
1010 1020 1030 1040 1050
PALAAESERT IPVQVNGKVR FTLQVPDGAA EPVIRELLTA HPDYARQTEG
1060
RTIKKTIIVP GRIVNIALG
Length:1,069
Mass (Da):116,994
Last modified:September 5, 2006 - v1
Checksum:i392D3E9F711BC099
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64833.1.
RefSeqiWP_011607260.1. NC_008278.1.
YP_716348.1. NC_008278.1.

Genome annotation databases

GeneIDi4237482.
KEGGifal:FRAAL6210.
PATRICi21921492. VBIFraAln347_5688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64833.1 .
RefSeqi WP_011607260.1. NC_008278.1.
YP_716348.1. NC_008278.1.

3D structure databases

ProteinModelPortali Q0RCJ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL6210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4237482.
KEGGi fal:FRAAL6210.
PATRICi 21921492. VBIFraAln347_5688.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FALN326424:GJ82-6107-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiSYL_FRAAA
AccessioniPrimary (citable) accession number: Q0RCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3