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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei841ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FRAAL6210
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347581 – 1069Leucine--tRNA ligaseAdd BLAST1069

Proteomic databases

PRIDEiQ0RCJ1

Interactioni

Protein-protein interaction databases

STRINGi326424.FRAAL6210

Structurei

3D structure databases

ProteinModelPortaliQ0RCJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 118"HIGH" regionAdd BLAST12
Motifi838 – 842"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 3 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 2 hits
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits

Sequencei

Sequence statusi: Complete.

Q0RCJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGRRTNEL GWHERMSETA EHGTGAANAT ASPSGAVPPS GATATAGTGD
60 70 80 90 100
EPGFRYDARL AADIERRWQR RWADEGTFNS PNPVGPLAAG FDEVAGREPF
110 120 130 140 150
YIMDMFPYPS GTGLHVGHPL GYIGTDVFAR YLRMSGRHVL HPFGYDAFGL
160 170 180 190 200
PAEQYAINTG QHPRTTTDAN IANMRRQLSR LGLGHDTRRE IATTDVGYYR
210 220 230 240 250
WTQWIFEQIF DAWYDPQAGR ARPIAELIAE FEAGTRSPAA GPAAGTTAVS
260 270 280 290 300
VDAVRAANPT GLPWAELDRV TRRRVVDAHR LAYISEQLVN WCPGLGTVLA
310 320 330 340 350
NEEVTAEGRS DIGNYPVFRR PLRQWVLRIT AYAERLVDDL DLVDWSDSIK
360 370 380 390 400
QMQRNWIGPS DGAGVEFAVV PPSGSAGAAP GQRIEVYTTR PDTLAGATFL
410 420 430 440 450
VLAPEHPQVD ALVADAWPAG TPGAWRFPAG RGPAVGEAAE VAAEEVAAEE
460 470 480 490 500
VGAAEVEAAA ADPAWTPRAA VEAYRAFAAR RSDRQRGEEV DRTGVFTGAY
510 520 530 540 550
VRNPVGGGLL PVFLADYVLV GYGTGAIMAV PAHDSRDFSF ARAFDLPIPA
560 570 580 590 600
VLAPDEQWYA EHRVTPGAPP SAWPEAFGGE GAYLPGPAGT PVLAGLTKPD
610 620 630 640 650
AIKTTVRWLE DGGHGRLARS YRLRDWLFSR QRYWGEPFPI VFDDDGLPYA
660 670 680 690 700
VPDELLPVEL PEMTDFRPTA MAEDDESDPV PPLARVADWA SVTLDLGDGP
710 720 730 740 750
KRYRRETNTM PQWAGSCWYH LRYLDPTNTE RFVDETVERY WLAKPGAAAG
760 770 780 790 800
DGGVDLYVGG VEHAVLHLLY ARFWQKVLYD LGHVSSKEPF KRLFNQGYIQ
810 820 830 840 850
ADAFTDARGM YVPAAEVKQT DDGRFTHHGA PVDRRSGKMG KSLKNSVSPD
860 870 880 890 900
EMYERFGADT LRVYEMAMGP LDADRPWHTD DIVGSHRFLQ RLWRAVVDEG
910 920 930 940 950
SGTVAVSDEQ LDAEATRVLH RTIITLAAEY AGLRFNTAVA RLIELTNYVS
960 970 980 990 1000
KRYGQAATPR ALAEPLVLMV APLAPHIAEE LWTRLGHSES VSRAAFPVGD
1010 1020 1030 1040 1050
PALAAESERT IPVQVNGKVR FTLQVPDGAA EPVIRELLTA HPDYARQTEG
1060
RTIKKTIIVP GRIVNIALG
Length:1,069
Mass (Da):116,994
Last modified:September 5, 2006 - v1
Checksum:i392D3E9F711BC099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA Translation: CAJ64833.1

Genome annotation databases

KEGGifal:FRAAL6210

Similar proteinsi

Entry informationi

Entry nameiSYL_FRAAA
AccessioniPrimary (citable) accession number: Q0RCJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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