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Q0RC35

- PANC3_FRAAA

UniProt

Q0RC35 - PANC3_FRAAA

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Protein
Pantothenate synthetase 3
Gene
panC3, FRAAL6371
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donor By similarity
Binding sitei62 – 621Beta-alanine By similarity
Binding sitei62 – 621Pantoate By similarity
Binding sitei160 – 1601Pantoate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATP By similarity
Nucleotide bindingi154 – 1574ATP By similarity
Nucleotide bindingi191 – 1944ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-6267-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 3 (EC:6.3.2.1)
Short name:
PS 3
Alternative name(s):
Pantoate--beta-alanine ligase 3
Pantoate-activating enzyme 3
Gene namesi
Name:panC3
Ordered Locus Names:FRAAL6371
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Pantothenate synthetase 3UniRule annotation
PRO_0000305455Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL6371.

Structurei

3D structure databases

ProteinModelPortaliQ0RC35.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiTETIFPL.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RC35-1 [UniParc]FASTAAdd to Basket

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MLRVLHTIED VREQTREWRA AGSSIGCVMT MGALHEGHLS LVDAARRECD    50
KVVLTLFVNP IQFGPSEDFD RYPRTEEADF RALRDRECDA VFAPATETIF 100
PLGERRIDQV RTKVVVRGLT DVLCGPRRPG HFDGVTTEVL KMLHIVDCDR 150
TYWGEKDYQQ YAVIRAMVED QGLPVKVVPC PTMRDVDGLA LSSRNTYLDS 200
GQRAIAPRLY AALRRGARRI AEQGIDVIGE TTKQIAETLL AHGFDLVEYV 250
EVYTGSLGPA VAGTPVEELR VFGAVRLGGA RLLDNAAVAD EVGG 294
Length:294
Mass (Da):32,511
Last modified:September 5, 2006 - v1
Checksum:iDF3A6AE9A22D1B1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64994.1.
RefSeqiWP_011607417.1. NC_008278.1.
YP_716505.1. NC_008278.1.

Genome annotation databases

GeneIDi4233711.
KEGGifal:FRAAL6371.
PATRICi21921770. VBIFraAln347_5824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ64994.1 .
RefSeqi WP_011607417.1. NC_008278.1.
YP_716505.1. NC_008278.1.

3D structure databases

ProteinModelPortali Q0RC35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL6371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4233711.
KEGGi fal:FRAAL6371.
PATRICi 21921770. VBIFraAln347_5824.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi TETIFPL.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci FALN326424:GJ82-6267-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiPANC3_FRAAA
AccessioniPrimary (citable) accession number: Q0RC35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3