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Protein

Pantothenate synthetase 4

Gene

panC4

Organism
Frankia alni (strain ACN14a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathway: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase 3 (panC3), Pantothenate synthetase 4 (panC4), Pantothenate synthetase 2 (panC2), Pantothenate synthetase 1 (panC1)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Proton donorUniRule annotation
Binding sitei82 – 821Beta-alanineUniRule annotation
Binding sitei82 – 821PantoateUniRule annotation
Binding sitei172 – 1721PantoateUniRule annotation
Binding sitei195 – 1951ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATPUniRule annotation
Nucleotide bindingi166 – 1694ATPUniRule annotation
Nucleotide bindingi203 – 2064ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-6566-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 4UniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PS 4UniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligase 4UniRule annotation
Pantoate-activating enzyme 4UniRule annotation
Gene namesi
Name:panC4UniRule annotation
Ordered Locus Names:FRAAL6670
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
ProteomesiUP000000657 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Pantothenate synthetase 4PRO_0000305456Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL6670.

Structurei

3D structure databases

ProteinModelPortaliQ0RB94.
SMRiQ0RB94. Positions 45-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RB94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVRDRAELR AALVALDRAA SSHPPAAAQD AGPARAASRH DRPVRAVVMT
60 70 80 90 100
MGALHEGHAS LLRAARARAD QVVATIFVNP LQFGAGEDLD RYPRTLAADL
110 120 130 140 150
AVCAREGVDV VFAPAVIHDP PPLVRFGAGP LGAVLEGASR PGHFDGMLTL
160 170 180 190 200
VGTMLHLVQP DLAFFGRKDA QQLVCIRRMV ADLAFDVTVI GVETAREPDG
210 220 230 240 250
LARSSRNVYL TAEQRTEALA LSRALAAGAA ASADGAPAVL AAARAVLDAA
260 270 280 290 300
DGVDVDYLEL AGPEDLGPVR GGPALLLVAA RVGTTRLIDN VSLILPTDTQ

GA
Length:302
Mass (Da):31,350
Last modified:September 5, 2006 - v1
Checksum:iCD83BD88735FEE29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ65293.1.
RefSeqiWP_011607707.1. NC_008278.1.
YP_716797.1. NC_008278.1.

Genome annotation databases

KEGGifal:FRAAL6670.
PATRICi21922318. VBIFraAln347_6094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573213 Genomic DNA. Translation: CAJ65293.1.
RefSeqiWP_011607707.1. NC_008278.1.
YP_716797.1. NC_008278.1.

3D structure databases

ProteinModelPortaliQ0RB94.
SMRiQ0RB94. Positions 45-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326424.FRAAL6670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGifal:FRAAL6670.
PATRICi21922318. VBIFraAln347_6094.

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciFALN326424:GJ82-6566-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiPANC4_FRAAA
AccessioniPrimary (citable) accession number: Q0RB94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.