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Q0RB94

- PANC4_FRAAA

UniProt

Q0RB94 - PANC4_FRAAA

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Protein

Pantothenate synthetase 4

Gene
panC4, FRAAL6670
Organism
Frankia alni (strain ACN14a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Proton donor By similarity
Binding sitei82 – 821Beta-alanine By similarity
Binding sitei82 – 821Pantoate By similarity
Binding sitei172 – 1721Pantoate By similarity
Binding sitei195 – 1951ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATP By similarity
Nucleotide bindingi166 – 1694ATP By similarity
Nucleotide bindingi203 – 2064ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFALN326424:GJ82-6566-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 4 (EC:6.3.2.1)
Short name:
PS 4
Alternative name(s):
Pantoate--beta-alanine ligase 4
Pantoate-activating enzyme 4
Gene namesi
Name:panC4
Ordered Locus Names:FRAAL6670
OrganismiFrankia alni (strain ACN14a)
Taxonomic identifieri326424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000000657: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Pantothenate synthetase 4UniRule annotationPRO_0000305456Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi326424.FRAAL6670.

Structurei

3D structure databases

ProteinModelPortaliQ0RB94.
SMRiQ0RB94. Positions 45-297.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0RB94-1 [UniParc]FASTAAdd to Basket

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MLVRDRAELR AALVALDRAA SSHPPAAAQD AGPARAASRH DRPVRAVVMT    50
MGALHEGHAS LLRAARARAD QVVATIFVNP LQFGAGEDLD RYPRTLAADL 100
AVCAREGVDV VFAPAVIHDP PPLVRFGAGP LGAVLEGASR PGHFDGMLTL 150
VGTMLHLVQP DLAFFGRKDA QQLVCIRRMV ADLAFDVTVI GVETAREPDG 200
LARSSRNVYL TAEQRTEALA LSRALAAGAA ASADGAPAVL AAARAVLDAA 250
DGVDVDYLEL AGPEDLGPVR GGPALLLVAA RVGTTRLIDN VSLILPTDTQ 300
GA 302
Length:302
Mass (Da):31,350
Last modified:September 5, 2006 - v1
Checksum:iCD83BD88735FEE29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ65293.1.
RefSeqiYP_716797.1. NC_008278.1.

Genome annotation databases

GeneIDi4233712.
KEGGifal:FRAAL6670.
PATRICi21922318. VBIFraAln347_6094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT573213 Genomic DNA. Translation: CAJ65293.1 .
RefSeqi YP_716797.1. NC_008278.1.

3D structure databases

ProteinModelPortali Q0RB94.
SMRi Q0RB94. Positions 45-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326424.FRAAL6670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4233712.
KEGGi fal:FRAAL6670.
PATRICi 21922318. VBIFraAln347_6094.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci FALN326424:GJ82-6566-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACN14a.

Entry informationi

Entry nameiPANC4_FRAAA
AccessioniPrimary (citable) accession number: Q0RB94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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