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Q0RB94 (PANC4_FRAAA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate synthetase 4

Short name=PS 4
EC=6.3.2.1
Alternative name(s):
Pantoate--beta-alanine ligase 4
Pantoate-activating enzyme 4
Gene names
Name:panC4
Ordered Locus Names:FRAAL6670
OrganismFrankia alni (strain ACN14a) [Complete proteome] [HAMAP]
Taxonomic identifier326424 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Pantothenate synthetase 4 HAMAP-Rule MF_00158
PRO_0000305456

Regions

Nucleotide binding51 – 588ATP By similarity
Nucleotide binding166 – 1694ATP By similarity
Nucleotide binding203 – 2064ATP By similarity

Sites

Active site581Proton donor By similarity
Binding site821Beta-alanine By similarity
Binding site821Pantoate By similarity
Binding site1721Pantoate By similarity
Binding site1951ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0RB94 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: CD83BD88735FEE29

FASTA30231,350
        10         20         30         40         50         60 
MLVRDRAELR AALVALDRAA SSHPPAAAQD AGPARAASRH DRPVRAVVMT MGALHEGHAS 

        70         80         90        100        110        120 
LLRAARARAD QVVATIFVNP LQFGAGEDLD RYPRTLAADL AVCAREGVDV VFAPAVIHDP 

       130        140        150        160        170        180 
PPLVRFGAGP LGAVLEGASR PGHFDGMLTL VGTMLHLVQP DLAFFGRKDA QQLVCIRRMV 

       190        200        210        220        230        240 
ADLAFDVTVI GVETAREPDG LARSSRNVYL TAEQRTEALA LSRALAAGAA ASADGAPAVL 

       250        260        270        280        290        300 
AAARAVLDAA DGVDVDYLEL AGPEDLGPVR GGPALLLVAA RVGTTRLIDN VSLILPTDTQ 


GA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT573213 Genomic DNA. Translation: CAJ65293.1.
RefSeqYP_716797.1. NC_008278.1.

3D structure databases

ProteinModelPortalQ0RB94.
SMRQ0RB94. Positions 45-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326424.FRAAL6670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4233712.
KEGGfal:FRAAL6670.
PATRIC21922318. VBIFraAln347_6094.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMAPTHFAGM.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

BioCycFALN326424:GJ82-6566-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANC4_FRAAA
AccessionPrimary (citable) accession number: Q0RB94
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways