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Protein

Probable citrate synthase, mitochondrial

Gene
N/A
Organism
Glossina morsitans morsitans (Savannah tsetse fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable citrate synthase, mitochondrial
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303PROSITE-ProRule annotation1
Active sitei349PROSITE-ProRule annotation1
Active sitei404PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
OrganismiGlossina morsitans morsitans (Savannah tsetse fly)
Taxonomic identifieri37546 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina
Proteomesi
  • UP000092444 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000291557? – 465Probable citrate synthase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiQ0QHL3

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0QHL3
SMRiQ0QHL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR010109 Citrate_synthase_euk
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01793 cit_synth_euk, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0QHL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIYRISTTR KMPEVQKLNA LLASYVRFIS ADSSLRDVLA AKIPAEQERV
60 70 80 90 100
KNFRKQHGSF KMGETTVDMM YGGMRGIKAL VTETSVLDAD EGIRFRGLSI
110 120 130 140 150
PECQKVLPAA DGGEEPLPEG LFWLLLTGEV PSKAQVKQVS REWAARAALP
160 170 180 190 200
QHVVTMLNNF PTSLHPMSQF SAAITALNHD SKFAKAYSDG VHKSKYWEHV
210 220 230 240 250
YEDSMDLIAK LPVVAATIYC NTYRNGKGSK SIDSSLDWSA NFVKMLGYDD
260 270 280 290 300
PKFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLRKLQKE AGSNPSEEQL KEYIWKTLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDELFQLVS KIYKVVPPIL QETGKVKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER
460
PKSLSTDLLM KMVQK
Length:465
Mass (Da):51,864
Last modified:September 5, 2006 - v1
Checksum:i8584A6B0BA0E84C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ374006 mRNA Translation: ABG77984.1

Similar proteinsi

Entry informationi

Entry nameiCISY_GLOMM
AccessioniPrimary (citable) accession number: Q0QHL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health