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Q0QHL3

- CISY_GLOMM

UniProt

Q0QHL3 - CISY_GLOMM

Protein

Probable citrate synthase, mitochondrial

Gene
N/A
Organism
Glossina morsitans morsitans (Savannah tsetse fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031PROSITE-ProRule annotation
    Active sitei349 – 3491PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable citrate synthase, mitochondrial (EC:2.3.3.16)
    OrganismiGlossina morsitans morsitans (Savannah tsetse fly)
    Taxonomic identifieri37546 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 465Probable citrate synthase, mitochondrialPRO_0000291557
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ0QHL3.
    SMRiQ0QHL3. Positions 30-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0QHL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIYRISTTR KMPEVQKLNA LLASYVRFIS ADSSLRDVLA AKIPAEQERV    50
    KNFRKQHGSF KMGETTVDMM YGGMRGIKAL VTETSVLDAD EGIRFRGLSI 100
    PECQKVLPAA DGGEEPLPEG LFWLLLTGEV PSKAQVKQVS REWAARAALP 150
    QHVVTMLNNF PTSLHPMSQF SAAITALNHD SKFAKAYSDG VHKSKYWEHV 200
    YEDSMDLIAK LPVVAATIYC NTYRNGKGSK SIDSSLDWSA NFVKMLGYDD 250
    PKFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG 300
    PLHGLANQEV LVWLRKLQKE AGSNPSEEQL KEYIWKTLKS GQVVPGYGHA 350
    VLRKTDPRYT CQREFALKHL PNDELFQLVS KIYKVVPPIL QETGKVKNPW 400
    PNVDAHSGVL LQYYGMKEMN YYTVLFGVSR ALGVLASLVW DRALGLPIER 450
    PKSLSTDLLM KMVQK 465
    Length:465
    Mass (Da):51,864
    Last modified:September 5, 2006 - v1
    Checksum:i8584A6B0BA0E84C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ374006 mRNA. Translation: ABG77984.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ374006 mRNA. Translation: ABG77984.1 .

    3D structure databases

    ProteinModelPortali Q0QHL3.
    SMRi Q0QHL3. Positions 30-463.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans."
      Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.
      Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fat body.

    Entry informationi

    Entry nameiCISY_GLOMM
    AccessioniPrimary (citable) accession number: Q0QHL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3