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Q0QHL3 (CISY_GLOMM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.1
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
Taxonomic identifier37546 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaHippoboscoideaGlossinidaeGlossina

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 465Probable citrate synthase, mitochondrialPRO_0000291557

Sites

Active site3031 By similarity
Active site3491 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0QHL3 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 8584A6B0BA0E84C6

FASTA46551,864
        10         20         30         40         50         60 
MSIYRISTTR KMPEVQKLNA LLASYVRFIS ADSSLRDVLA AKIPAEQERV KNFRKQHGSF 

        70         80         90        100        110        120 
KMGETTVDMM YGGMRGIKAL VTETSVLDAD EGIRFRGLSI PECQKVLPAA DGGEEPLPEG 

       130        140        150        160        170        180 
LFWLLLTGEV PSKAQVKQVS REWAARAALP QHVVTMLNNF PTSLHPMSQF SAAITALNHD 

       190        200        210        220        230        240 
SKFAKAYSDG VHKSKYWEHV YEDSMDLIAK LPVVAATIYC NTYRNGKGSK SIDSSLDWSA 

       250        260        270        280        290        300 
NFVKMLGYDD PKFTELMRLY LTIHSDHEGG NVSAHTVHLV GSALSDPYLS FAAGMNGLAG 

       310        320        330        340        350        360 
PLHGLANQEV LVWLRKLQKE AGSNPSEEQL KEYIWKTLKS GQVVPGYGHA VLRKTDPRYT 

       370        380        390        400        410        420 
CQREFALKHL PNDELFQLVS KIYKVVPPIL QETGKVKNPW PNVDAHSGVL LQYYGMKEMN 

       430        440        450        460 
YYTVLFGVSR ALGVLASLVW DRALGLPIER PKSLSTDLLM KMVQK 

« Hide

References

[1]"Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans."
Attardo G.M., Strickler-Dinglasan P., Perkin S.A.H., Caler E., Bonaldo M.F., Soares M.B., El-Sayeed N.M.A., Aksoy S.
Insect Mol. Biol. 15:411-424(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fat body.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ374006 mRNA. Translation: ABG77984.1.

3D structure databases

ProteinModelPortalQ0QHL3.
SMRQ0QHL3. Positions 30-463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_GLOMM
AccessionPrimary (citable) accession number: Q0QHL3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 5, 2006
Last modified: October 16, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways