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Q0QF17 (SDHA_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Flavoprotein subunit of complex II
Short name=Fp
Gene names
Name:SDHA
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length551 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. Can act as a tumor suppressor By similarity. UniProtKB P31040

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD By similarity. UniProtKB P31040

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. UniProtKB P31040

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity. UniProtKB P31040

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity UniProtKB P31040.

Post-translational modification

Phosphorylation at Tyr-157 is important for efficient electron transfer in complex II and the prevention of ROS generation By similarity.

Deacetylated by SIRT3 By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›551›551Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
PRO_0000394746

Regions

Nucleotide binding10 – 156FAD By similarity UniProtKB Q9YHT1
Nucleotide binding33 – 4816FAD By similarity UniProtKB Q9YHT1
Nucleotide binding398 – 3992FAD By similarity UniProtKB Q9YHT1

Sites

Active site2821Proton acceptor By similarity UniProtKB Q9YHT1
Binding site2171FAD By similarity UniProtKB Q9YHT1
Binding site2381Substrate By similarity UniProtKB Q9YHT1
Binding site2501Substrate By similarity UniProtKB Q9YHT1
Binding site3491Substrate By similarity UniProtKB Q9YHT1
Binding site3821FAD By similarity UniProtKB Q9YHT1
Binding site3931Substrate By similarity UniProtKB Q9YHT1

Amino acid modifications

Modified residue411Tele-8alpha-FAD histidine By similarity UniProtKB Q9YHT1
Modified residue1091N6-acetyllysine By similarity
Modified residue1211N6-acetyllysine; alternate By similarity
Modified residue1211N6-succinyllysine; alternate By similarity
Modified residue1241N6-acetyllysine By similarity
Modified residue1571Phosphotyrosine; by SRC By similarity
Modified residue1921N6-acetyllysine; alternate By similarity
Modified residue1921N6-succinyllysine; alternate By similarity
Modified residue2771N6-acetyllysine; alternate By similarity
Modified residue2771N6-succinyllysine; alternate By similarity
Modified residue3651N6-acetyllysine By similarity UniProtKB Q8K2B3
Modified residue4221N6-acetyllysine By similarity
Modified residue4271N6-acetyllysine; alternate By similarity
Modified residue4271N6-succinyllysine; alternate By similarity
Modified residue4401N6-acetyllysine; alternate By similarity
Modified residue4401N6-succinyllysine; alternate By similarity
Modified residue4591N6-acetyllysine By similarity
Modified residue4801N6-acetyllysine; alternate By similarity
Modified residue4801N6-succinyllysine; alternate By similarity
Modified residue4891N6-acetyllysine; alternate By similarity
Modified residue4891N6-succinyllysine; alternate By similarity
Modified residue4921N6-acetyllysine By similarity
Modified residue5401N6-acetyllysine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue5511

Sequences

Sequence LengthMass (Da)Tools
Q0QF17 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 13CB219D31B9B678

FASTA55160,045
        10         20         30         40         50         60 
DHEFDAVVVG AGGAGLRAAF GLSEAGFNTA CGTKLFPTRS HTVAAQGGIN AALGNMEEDN 

        70         80         90        100        110        120 
WRWHFYDTVK GSDWLGDQDA IHYMTEQAPA SVVELENYGM PFSTTEDGKI YQRAFGGQSL 

       130        140        150        160        170        180 
KFGKGGQAHR SCCVADRTGH SLLHTLYGRS LRYDTSYFVE NFALDLLMEN GECRGVIALC 

       190        200        210        220        230        240 
IEDGSIHRIR AKNTVIATGG YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFIQFHPT 

       250        260        270        280        290        300 
GIYGAGCLIT EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRSWG 

       310        320        330        340        350        360 
PEKDHVYLQL HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY NMGGIPTNYK 

       370        380        390        400        410        420 
GQVLKHVNGQ DQVVPGLYAC GEAACASVHG AIRLGANSLL DLVVFGRACA LSIAESCSPG 

       430        440        450        460        470        480 
DKVPPIKANA GEESVMNLDK LRFADGSIRT SELRLSMQKS MQSHAAVFRV GSVLQEGCEK 

       490        500        510        520        530        540 
ISQLYGELKH LKTFDRGMVW NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK 

       550 
VRVDEYDYYX A 

« Hide

References

[1]"Housekeeping genes for phylogenetic analysis of eutherian relationships."
Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ402977 mRNA. Translation: ABD77310.1.

3D structure databases

ProteinModelPortalQ0QF17.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ0QF17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001461.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_MESAU
AccessionPrimary (citable) accession number: Q0QF17
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways