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Q0QF17

- SDHA_MESAU

UniProt

Q0QF17 - SDHA_MESAU

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDHA

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei217 – 2171FADBy similarity
    Binding sitei238 – 2381SubstrateBy similarity
    Binding sitei250 – 2501SubstrateBy similarity
    Active sitei282 – 2821Proton acceptorBy similarity
    Binding sitei349 – 3491SubstrateBy similarity
    Binding sitei382 – 3821FADBy similarity
    Binding sitei393 – 3931SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADBy similarity
    Nucleotide bindingi33 – 4816FADBy similarityAdd
    BLAST
    Nucleotide bindingi398 – 3992FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialBy similarity (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex IIBy similarity
    Short name:
    FpBy similarity
    Gene namesi
    Name:SDHAImported
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›551›551Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000394746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411Tele-8alpha-FAD histidineBy similarity
    Modified residuei109 – 1091N6-acetyllysineBy similarity
    Modified residuei121 – 1211N6-acetyllysine; alternateBy similarity
    Modified residuei121 – 1211N6-succinyllysine; alternateBy similarity
    Modified residuei124 – 1241N6-acetyllysineBy similarity
    Modified residuei157 – 1571Phosphotyrosine; by SRCBy similarity
    Modified residuei192 – 1921N6-acetyllysine; alternateBy similarity
    Modified residuei192 – 1921N6-succinyllysine; alternateBy similarity
    Modified residuei277 – 2771N6-acetyllysine; alternateBy similarity
    Modified residuei277 – 2771N6-succinyllysine; alternateBy similarity
    Modified residuei365 – 3651N6-acetyllysineBy similarity
    Modified residuei422 – 4221N6-acetyllysineBy similarity
    Modified residuei427 – 4271N6-acetyllysine; alternateBy similarity
    Modified residuei427 – 4271N6-succinyllysine; alternateBy similarity
    Modified residuei440 – 4401N6-acetyllysine; alternateBy similarity
    Modified residuei440 – 4401N6-succinyllysine; alternateBy similarity
    Modified residuei459 – 4591N6-acetyllysineBy similarity
    Modified residuei480 – 4801N6-acetyllysine; alternateBy similarity
    Modified residuei480 – 4801N6-succinyllysine; alternateBy similarity
    Modified residuei489 – 4891N6-acetyllysine; alternateBy similarity
    Modified residuei489 – 4891N6-succinyllysine; alternateBy similarity
    Modified residuei492 – 4921N6-acetyllysineBy similarity
    Modified residuei540 – 5401N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Tyr-157 is important for efficient electron transfer in complex II and the prevention of ROS generation.By similarity
    Deacetylated by SIRT3.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ0QF17.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ0QF17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG001461.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q0QF17-1 [UniParc]FASTAAdd to Basket

    « Hide

    DHEFDAVVVG AGGAGLRAAF GLSEAGFNTA CGTKLFPTRS HTVAAQGGIN    50
    AALGNMEEDN WRWHFYDTVK GSDWLGDQDA IHYMTEQAPA SVVELENYGM 100
    PFSTTEDGKI YQRAFGGQSL KFGKGGQAHR SCCVADRTGH SLLHTLYGRS 150
    LRYDTSYFVE NFALDLLMEN GECRGVIALC IEDGSIHRIR AKNTVIATGG 200
    YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFIQFHPT GIYGAGCLIT 250
    EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRSWG 300
    PEKDHVYLQL HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY 350
    NMGGIPTNYK GQVLKHVNGQ DQVVPGLYAC GEAACASVHG AIRLGANSLL 400
    DLVVFGRACA LSIAESCSPG DKVPPIKANA GEESVMNLDK LRFADGSIRT 450
    SELRLSMQKS MQSHAAVFRV GSVLQEGCEK ISQLYGELKH LKTFDRGMVW 500
    NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK VRVDEYDYYX 550
    A 551
    Length:551
    Mass (Da):60,045
    Last modified:September 5, 2006 - v1
    Checksum:i13CB219D31B9B678
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei551 – 5511Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ402977 mRNA. Translation: ABD77310.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ402977 mRNA. Translation: ABD77310.1 .

    3D structure databases

    ProteinModelPortali Q0QF17.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q0QF17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001461.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
      Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: LiverImported.
    2. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSDHA_MESAU
    AccessioniPrimary (citable) accession number: Q0QF17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3